Influence of processing conditions in the manufacture of O/W creams - I. Effect on dispersion grade and rheological characteristics

被引:6
作者
Realdon, N [1 ]
Perin, F [1 ]
Morpurgo, M [1 ]
Ragazzi, E [1 ]
机构
[1] Univ Padua, Fac Pharm, Dept Pharmaceut Sci, I-35131 Padua, Italy
来源
FARMACO | 2002年 / 57卷 / 05期
关键词
O/W creams; polyoxyethylene-cetostearyl alcohols; polyglyceryl-3-methylglucose-distearate;
D O I
10.1016/S0014-827X(02)01213-2
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Two series of O/W creams having the same general formulation were prepared in three different mechanical conditions (F with an hand blender; S with a turbomixer; T with a vacuum turbo emulsor) using two types of surfactants, polyoxyethylene-cetostearyl alcohols and polyglyceryl-3-methylglucose-distearate. By means of microscopic image analysis it was possible to point out the dispersion grade of the oil internal phase increasing with the energy applied under the conditions of manufacture (F<S<T). The level of dispersion influenced significantly on the rheological characteristics of the creams. With polyoxyethylenecetostearyl alcohols, the viscosity of creams increased as the energy applied in manufacturing increased, with polyglyceryl-3-methylglucose-distearate on the contrary decreased. Moreover, indifferently to the manufacturing conditions, even in the same concentration of surfactant, the creams obtained with the last produced a much greater viscosity. At a parity of manufacturing conditions the differences between the batches of productions were not significant. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码:341 / 347
页数:7
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