Combined effect of volumetric breast density and body mass index on breast cancer risk

被引：21

作者：

Engmann, Natalie J. ^{[1
]}

Scott, Christopher G. ^{[2
]}

Jensen, Matthew R. ^{[2
]}

Winham, Stacey ^{[2
]}

Miglioretti, Diana L. ^{[3
,4
]}

Ma, Lin ^{[5
]}

Brandt, Kathleen ^{[2
]}

Mahmoudzadeh, Amir ^{[6
]}

Whaley, Dana H. ^{[2
]}

Hruska, Carrie ^{[2
]}

Wu, Fang ^{[2
]}

Norman, Aaron D. ^{[2
]}

Hiatt, Robert A. ^{[7
]}

Heine, John ^{[8
]}

Shepherd, John ^{[9
]}

Pankratz, V. Shane ^{[10
]}

Vachon, Celine M. ^{[2
]}

Kerlikowske, Karla ^{[7
]}

机构：

[1] Genentech Inc, San Francisco, CA 94080 USA

[2] Mayo Clin, Rochester, MN USA

[3] Univ Calif Davis, Davis, CA 95616 USA

[4] Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA

[5] Kaiser Permanente Div Res, Oakland, CA USA

[6] Accenture, San Francisco, CA USA

[7] Univ Calif San Francisco, Dept Med & Epidemiol & Biostat, San Francisco, CA 94143 USA

[8] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA

[9] Univ Hawaii, Honolulu, HI 96822 USA

[10] Univ New Mexico, Hlth Sci Ctr, Albuquerque, NM 87131 USA

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2019年 / 177卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Breast density; Mammographic density; Breast cancer; Body mass index; MAMMOGRAPHIC DENSITY; SUBSEQUENT RISK; WOMENS HEALTH; ASSOCIATION; ADIPOSITY; SIZE; AREAS;

D O I：

10.1007/s10549-019-05283-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundBreast density and body mass index (BMI) are used for breast cancer risk stratification. We evaluate whether the positive association between volumetric breast density and breast cancer risk is strengthened with increasing BMI.MethodsThe San Francisco Mammography Registry and Mayo Clinic Rochester identified 781 premenopausal and 1850 postmenopausal women with breast cancer diagnosed between 2007 and 2015 that had a screening digital mammogram at least 6months prior to diagnosis. Up to three controls (N=3535) were matched per case on age, race, date, mammography machine, and state. Volumetric percent density (VPD) and dense volume (DV) were measured with Volpara (TM). Breast cancer risk was assessed with logistic regression stratified by menopause status. Multiplicative interaction tests assessed whether the association of density measures was differential by BMI categories.ResultsThe increased risk of breast cancer associated with VPD was strengthened with higher BMI for both premenopausal (p(interaction)=0.01) and postmenopausal (p(interaction)=0.0003) women. For BMI<25, 25-30, and >= 30kg/m(2), ORs for breast cancer for a 1SD increase in VPD were 1.24, 1.65, and 1.97 for premenopausal, and 1.20, 1.55, and 2.25 for postmenopausal women, respectively. ORs for breast cancer for a 1SD increase in DV were 1.39, 1.33, and 1.51 for premenopausal (p(interaction)=0.58), and 1.31, 1.34, and 1.65 (p(interaction)=0.03) for postmenopausal women for BMI<25, 25-30 and >= 30kg/m(2), respectively.ConclusionsThe effect of volumetric percent density on breast cancer risk is strongest in overweight and obese women. These associations have clinical relevance for informing prevention strategies.

引用

页码：165 / 173

页数：9

共 38 条

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