Metabolism Dysregulation in Retinal Diseases and Related Therapies

被引：22
作者：
Chen, Yingying [1 ,2 ]
Coorey, Nathan J. [3 ]
Zhang, Meixia [1 ,4 ]
Zeng, Shaoxue [2 ]
Madigan, Michele C. [2 ,5 ]
Zhang, Xinyuan [6 ,7 ]
Gillies, Mark C. [2 ]
Zhu, Ling [2 ]
Zhang, Ting [2 ]
机构：
[1] Sichuan Univ, West China Hosp, Dept Ophthalmol, Chengdu 610017, Peoples R China
[2] Univ Sydney, Fac Med & Hlth, Save Sight Inst, Sydney, NSW 2000, Australia
[3] Canberra Hlth Serv, Canberra, ACT 2605, Australia
[4] Sichuan Univ, West China Hosp, Dept Ophthalmol, Macular Dis Res Lab, Chengdu 610017, Peoples R China
[5] Univ New South Wales UNSW, Sch Optometry & Vis Sci, Sydney, NSW 2052, Australia
[6] Capital Med Univ, Tongren Hosp, Beijing Tongren Eye Ctr, Dept Ocular Fundus Dis, Beijing 100073, Peoples R China
[7] Beijing Retinal & Choroidal Vasc Study Grp, Beijing 100073, Peoples R China
来源：
ANTIOXIDANTS | 2022年 / 11卷 / 05期
基金：
英国医学研究理事会;
关键词：
retina; metabolism; retinal diseases; gene therapy; lipid metabolism; ENDOPLASMIC-RETICULUM STRESS; GLYCATION END-PRODUCTS; DIETARY GLYCEMIC INDEX; MACULAR DEGENERATION; OXIDATIVE STRESS; DOCOSAHEXAENOIC ACID; DIABETIC-RETINOPATHY; GLUCOSE-METABOLISM; ENERGY-METABOLISM; NMNAT1; MUTATIONS;
D O I：
10.3390/antiox11050942
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The human retina, which is part of the central nervous system, has exceptionally high energy demands that requires an efficient metabolism of glucose, lipids, and amino acids. Dysregulation of retinal metabolism disrupts local energy supply and redox balance, contributing to the pathogenesis of diverse retinal diseases, including age-related macular degeneration, diabetic retinopathy, inherited retinal degenerations, and Macular Telangiectasia. A better understanding of the contribution of dysregulated metabolism to retinal diseases may provide better therapeutic targets than we currently have.
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页数：17
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