Placental expression of PHLDA2 in selective intrauterine growth restriction in monozygotic twins

被引：17
|
作者：
Shi, X. [1 ]
He, Z. [1 ]
Gao, Y. [1 ]
Luo, Y. [1 ]
Gou, C. [1 ]
Fang, Q. [1 ]
机构：
[1] Sun Yat Sen Univ, Affiliated Hosp 1, Fatal Med Ctr, Guangzhou 510080, Guangdong, Peoples R China
来源：
PLACENTA | 2014年 / 35卷 / 06期
关键词：
PHLDA2; Monozygotic twin; sIUGR; Placenta; IMPRINTED GENES; DOMAINS;
D O I：
10.1016/j.placenta.2014.03.006
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Studies have showed that increase of placental expression of imprinted genes PHLDA2 may have a potential regulatory role in fetal IUGR (intrauterine growth restriction) in singleton. In this study, we investigate the expression level of PHLDA2 in placenta of monozygotic twins (MZT) with selective intrauterine growth restriction (sIUGR) and normal MZT. Both mRNA levels and protein levels of PHLDA2 were significantly increased in placenta sharings of small fetus in cases of sIUGR. Our results suggest upregulated PHLDA2 in placenta may be associated with the pathogenesis of sIUGR. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：428 / 430
页数：3
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