Clinical Utility of Laboratory Detection of Clostridium difficile Strain BI/NAP1/027

被引：15

作者：

Kociolek, Larry K. ^{[1
,2
]}

Gerding, Dale N. ^{[3
,4
]}

机构：

[1] Ann & Robert H Lurie Childrens Hosp Chicago, Infect Prevent & Control, Chicago, IL 60611 USA

[2] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA

[3] Edward Hines Jr Vet Affairs Hosp, Hines, IL USA

[4] Loyola Univ Chicago, Stritch Sch Med, Maywood, IL USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2016年 / 54卷 / 01期

关键词：

RESTRICTION-ENDONUCLEASE ANALYSIS; TANDEM-REPEAT ANALYSIS; C.-DIFFICILE; MOLECULAR EPIDEMIOLOGY; NAP1; STRAIN; INFECTION; SURVEILLANCE; EMERGENCE; CHILDREN; ASSAY;

D O I：

10.1128/JCM.02340-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Clostridium difficile strain BI/NAP1/027 is associated with increased C. difficile infection (CDI) rates and severity, and the efficacy of some CDI therapies may be strain dependent. Although cultured C. difficile isolates can be reliably subtyped by various methods, the long turnaround times, high cost, and limited availability of strain typing preclude their routine use. Nucleic acid amplification tests identify BI/NAP1/027 rapidly from stool, but the emergence of closely related strains compromises test specificity. Although detection of epidemiologically significant pathogens is generally useful for infection control programs, specific data supporting use of rapid detection of BI/NAP1/027 as an infection control tool are still awaited.

引用

页码：19 / 24

页数：6