The Molecular Mechanisms and Function of miR-15a/16 Dysregulation in Fibrotic Diseases

被引：6

作者：

Wen, Dada ^{[1
]}

Zhang, Huamin ^{[1
]}

Zhou, Yutong ^{[1
]}

Wang, Jie ^{[1
]}

机构：

[1] Cent South Univ, Xiangya Sch Med, Dept Immunol, Changsha 410078, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 24期

基金：

中国国家自然科学基金;

关键词：

miR-15a; miR-16; biological characteristics; fibrosis; functional mechanism; LIVER FIBROSIS; DOWN-REGULATION; MIR-16; EXPRESSION; ACTIVATION; CELL; INHIBITION; MICRORNAS; FAMILY; TARGET;

D O I：

10.3390/ijms232416041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) are a class of short, endogenous, non-coding, single-stranded RNAs that can negatively regulate the post-transcriptional expression of target genes. Among them, miR-15a/16 is involved in the regulation of the occurrence and development of fibrosis in the liver, lungs, heart, kidneys, and other organs, as well as systemic fibrotic diseases, affecting important cellular functions, such as cell transformation, the synthesis and degradation of extracellular matrix, and the release of fibrotic mediators. Therefore, this article reviews the biological characteristics of miR-15a/16 and the molecular mechanisms and functions of their dysregulation in fibrotic diseases.

引用

页数：13

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