The Molecular Mechanisms and Function of miR-15a/16 Dysregulation in Fibrotic Diseases

被引：7

作者：

Wen, Dada ^{[1
]}

Zhang, Huamin ^{[1
]}

Zhou, Yutong ^{[1
]}

Wang, Jie ^{[1
]}

机构：

[1] Cent South Univ, Xiangya Sch Med, Dept Immunol, Changsha 410078, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 24期

基金：

中国国家自然科学基金;

关键词：

miR-15a; miR-16; biological characteristics; fibrosis; functional mechanism; LIVER FIBROSIS; DOWN-REGULATION; MIR-16; EXPRESSION; ACTIVATION; CELL; INHIBITION; MICRORNAS; FAMILY; TARGET;

D O I：

10.3390/ijms232416041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) are a class of short, endogenous, non-coding, single-stranded RNAs that can negatively regulate the post-transcriptional expression of target genes. Among them, miR-15a/16 is involved in the regulation of the occurrence and development of fibrosis in the liver, lungs, heart, kidneys, and other organs, as well as systemic fibrotic diseases, affecting important cellular functions, such as cell transformation, the synthesis and degradation of extracellular matrix, and the release of fibrotic mediators. Therefore, this article reviews the biological characteristics of miR-15a/16 and the molecular mechanisms and functions of their dysregulation in fibrotic diseases.

引用

页数：13

共 50 条

[21] Elevated expressions of serum miR-15a, miR-16, and miR-17-5p are associated with acute ischemic stroke [J].

Wu, Jin ;

Du, Kang ;

Lu, Xiang .

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2015, 8 (11) :21071-21079

[22] Down-regulation of miR-15a/b accelerates fibrotic remodelling in the Type 2 diabetic human and mouse heart [J].

Rawal, Shruti ;

Munasinghe, Pujika Emani ;

Nagesh, Prashanth Thevkar ;

Lew, Jason Kar Sheng ;

Jones, Gregory T. ;

Williams, Michael J. A. ;

Davis, Philip ;

Bunton, Dick ;

Galvin, Ivor F. ;

Manning, Patrick ;

Lamberts, Regis R. ;

Katare, Rajesh .

CLINICAL SCIENCE, 2017, 131 (09) :847-863

[23] miR-15a and miR-16 regulate serotonin transporter expression in human placental and rat brain raphe cells [J].

Moya, Pablo R. ;

Wendland, Jens R. ;

Salemme, Jennifer ;

Fried, Ruby L. ;

Murphy, Dennis L. .

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2013, 16 (03) :621-629

[24] MiR-15a and MiR-16 Control Bmi-1 Expression in Ovarian Cancer [J].

Bhattacharya, Resham ;

Nicoloso, Milena ;

Arvizo, Rochelle ;

Wang, Enfeng ;

Cortez, Angelica ;

Rossi, Simona ;

Calin, George A. ;

Mukherjee, Priyabrata .

CANCER RESEARCH, 2009, 69 (23) :9090-9095

[25] Curcumin reduces the expression of Bcl-2 by upregulating miR-15a and miR-16 in MCF-7 cells [J].

Yang, Jie ;

Cao, Yunxin ;

Sun, Jifeng ;

Zhang, Yong .

MEDICAL ONCOLOGY, 2010, 27 (04) :1114-1118

[26] The Role of JAK/STAT Pathway in Fibrotic Diseases: Molecular and Cellular Mechanisms [J].

Liu, Jia ;

Wang, Faping ;

Luo, Fengming .

BIOMOLECULES, 2023, 13 (01)

[27] The DLEU2/miR-15a/miR-16-1 cluster shapes the immune microenvironment of chronic lymphocytic leukemia [J].

Zhang, Ronghua ;

Khare, Priyanka ;

Banerjee, Priyanka ;

Ivan, Cristina ;

Schneider, Sarah ;

Barbaglio, Federica ;

Clise-Dwyer, Karen ;

Jensen, Vanessa Behrana ;

Thompson, Erika ;

Mendoza, Marisela ;

Chiorazzi, Nicholas ;

Chen, Shih-Shih ;

Yan, Xiao-Jie Joy ;

Jain, Nitin ;

Ghia, Paolo ;

Caligaris-Cappio, Federico ;

Mendonsa, Rima ;

Kasimsetty, Sashi ;

Swoboda, Ryan ;

Bayraktar, Recep ;

Wierda, William ;

Gandhi, Varsha ;

Calin, George A. ;

Keating, Michael J. ;

Bertilaccio, Maria Teresa Sabrina .

BLOOD CANCER JOURNAL, 2024, 14 (01)

[28] Aloe-Emodin Induces Breast Tumor Cell Apoptosis through Upregulation of miR-15a/miR-16-1 That Suppresses BCL2 [J].

Jiang, Xuefeng ;

Liu, Yusheng ;

Zhang, Guijuan ;

Lin, Shujun ;

Wu, Jieyan ;

Yan, Xianxin ;

Ma, Yi ;

Ma, Min .

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2020, 2020

[29] Mitophagy in fibrotic diseases: molecular mechanisms and therapeutic applications [J].

Cui, Xinyan ;

Zhou, Zekun ;

Tu, Hua ;

Wu, Jianjun ;

Zhou, Jian ;

Yi, Qiao ;

Liu, Ousheng ;

Dai, Xiaohan .

FRONTIERS IN PHYSIOLOGY, 2024, 15

[30] miR-15a/miR-16 induces mitochondrial dependent apoptosis in breast cancer cells by suppressing oncogene BMI1 [J].

Patel, Nibedita ;

Garikapati, Koteswara Rao ;

Ramaiah, M. Janaki ;

Polavarapu, Kavi Kishor ;

Bhadra, Utpal ;

Bhadra, Manika Pal .

LIFE SCIENCES, 2016, 164 :60-70

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