ANK3 gene expression in bipolar disorder and schizophrenia

被引：30

作者：

Wirgenes, Katrine Verena ^{[1
,2
]}

Tesli, Martin ^{[1
]}

Inderhaug, Elin ^{[1
,3
]}

Athanasiu, Lavinia ^{[1
,3
]}

Agartz, Ingrid ^{[1
,2
,4
]}

Melle, Ingrid ^{[1
,2
]}

Hughes, Timothy ^{[3
]}

Andreassen, Ole Andreas ^{[1
,2
]}

Djurovic, Srdjan ^{[1
,3
]}

机构：

[1] Univ Oslo, KG Jebsen Ctr Psychosis Res, NORMENT, Inst Clin Med, Oslo, Norway

[2] Oslo Univ Hosp, Div Mental Hlth & Addict, N-0424 Oslo, Norway

[3] Oslo Univ Hosp, Dept Med Genet, N-0424 Oslo, Norway

[4] Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway

来源：

BRITISH JOURNAL OF PSYCHIATRY | 2014年 / 205卷 / 03期

关键词：

BRAIN; VARIANT;

D O I：

10.1192/bjp.bp.114.145433

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

ANK3 gene variants have consistently been associated with bipolar spectrum disorder and schizophrenia spectrum disorder. However, the relevance of its encoded protein, ankyrin-3, in these disorders remains elusive. Here, we show that ANK3 gene expression in blood is significantly increased in bipolar disorder and schizophrenia compared with healthy controls. Additionally, we identified potential cis-acting expression quantitative trait loci located close to the transcription start site of one of the isoforms of the gene. These findings suggest that ANK3 mRNA is an interesting marker for further investigation of the underlying mechanisms in psychotic disorders.

引用

页码：244 / +

页数：2

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