Total Synthesis of Sporolide B

被引：63

作者：

Nicolaou, K. C. ^{[1
]}

Tang, Yefeng

Wang, Jianhua

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 19期

基金：

美国国家卫生研究院;

关键词：

cycloaddition; Diels-Alder reactions; natural products; o-quinones; total synthesis; CYCLOADDITION; CHEMISTRY; ENEDIYNE; BIOLOGY; BENZYNE;

D O I：

10.1002/anie.200900264

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An ocean of discovery: The first total synthesis of the highly oxygenated, marine-derived, natural product sporolide B has been achieved through a convergent strategy. The key steps involve a rutheniumcatalyzed [2+2+2] cycloaddition to assemble the indene structural motif and a thermally induced Diels-Alder-type reaction to forge the macrocycle (see scheme). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3449 / 3453

页数：5

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