Preclinical models of pancreatic ductal adenocarcinoma

被引：85

作者：

Hwang, Chang-Il ^{[1
,2
]}

Boj, Sylvia F. ^{[3
,4
,5
]}

Clevers, Hans ^{[3
,4
]}

Tuveson, David A. ^{[1
,2
,6
]}

机构：

[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

[2] Lustgarten Fdn Pancreat Canc Res Lab, Cold Spring Harbor, NY USA

[3] Univ Med Ctr Utrecht, Royal Netherlands Acad Arts & Sci KNAW, Hubrecht Inst, Utrecht, Netherlands

[4] CancerGenomics Nl, Utrecht, Netherlands

[5] Fdn Hubrecht Organoid Technol HUB, Utrecht, Netherlands

[6] Mem Sloan Kettering Canc Ctr, Rubenstein Ctr Pancreat Canc Res, New York, NY 10021 USA

来源：

JOURNAL OF PATHOLOGY | 2016年 / 238卷 / 02期

基金：

美国国家卫生研究院;

关键词：

pancreatic cancer; organoid; preclinical model; patient-derived tumour xenograft; IN-VITRO EXPANSION; CANCER-CELL-LINES; STEM-CELLS; MOUSE MODEL; NUDE-MICE; PHASE-III; GEMCITABINE; VIVO; GROWTH; MUTATIONS;

D O I：

10.1002/path.4651

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic ductal adenocarcinoma (PDA) is one of the most difficult human malignancies to treat. The 5-year survival rate of PDA patients is 7% and PDA is predicted to become the second leading cancer-related cause of death in the USA. Despite intensive efforts, the translation of findings in preclinical studies has been ineffective, due partially to the lack of preclinical models that faithfully recapitulate features of human PDA. Here, we review current preclinical models for human PDA (eg human PDA cell lines, cell line-based xenografts and patient-derived tumour xenografts). In addition, we discuss potential applications of the recently developed pancreatic ductal organoids, three-dimensional culture systems and organoid-based xenografts as new preclinical models for PDA. Copyright (c) 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

引用

页码：197 / 204

页数：8

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