A new and convenient in-situ method of generating phenyl isocyanates from anilines using oxalyl chloride

被引：12

作者：

Oh, LM ^{[1
]}

Spoors, PG ^{[1
]}

Goodman, RM ^{[1
]}

机构：

[1] GlaxoSmithKline, Synth Chem, Chem Dev, King Of Prussia, PA 19406 USA

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 24期

关键词：

phenyl isocyanates; anilines; oxalyl chloride;

D O I：

10.1016/j.tetlet.2004.04.043

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and convenient method of generating phenyl isocyanates from anilines using oxalyl chloride is described. Acylation of a variety of substituted aniline hydrochlorides with oxalyl chloride affords the intermediate oxamic chlorides, which smoothly undergo thermal decomposition to the corresponding isocyanates. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：4769 / 4771

页数：3

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