NOVEL 16-BP INSERTION/DELETION VARIANT OF ZNF132 GENE AND ITS INFLUENCE ON GROWTH TRAITS IN GOATS

被引：0
作者：
Wang, X. Y. [1 ]
Yang, Q. [1 ]
Luo, J. [1 ]
Wang, Y. [1 ]
Feng, Q. [1 ]
Zhang, Z. H. [1 ]
Lei, C. Z. [1 ]
Chen, H. [1 ]
Lan, X. Y. [1 ]
机构：
[1] Northwest A&F Univ, Coll Anim Sci & Technol, Shaanxi Key Lab Mol Biol Agr, Yangling 712100, Shaanxi, Peoples R China
来源：
Journal of Animal and Plant Sciences | 2016年 / 26卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Goat; Zinc finger protein 132 (ZNF132) gene; insertion/deletion (indel) polymorphism; Growth traits; Association; BODY MEASUREMENT TRAITS; DAIRY GOATS; POLYMORPHISMS; ASSOCIATION; EXPRESSION; CATTLE; EUKARYOTES; ALLELE;
D O I：
暂无
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
Zinc finger protein 132 (ZNF132) is a transcriptional repressor and plays an important role in animal production traits. Insertion/deletion (indel) polymorphisms are relatively simple and effective DNA markers. The objective of this study was to explore the potential novel indel variants within the goat ZNF132 gene, as well as to evaluate their effects on growth traits. A novel 16-bp indel was first verified in a 5' untranslated region (UTR) of the ZNF132 gene, and three genotypes were detected. The minor allelic frequencies were 0.160 and zero in the Hainan black goat (HNBG) and Guanzhong dairy goat (GZ) breeds, respectively. Additionally, there were significant differences in the distribution of genotypic and allelic frequencies between these two breeds (P<0.01). An association analysis revealed that the 16-bp novel indel was significantly associated with the body length of the HNBG breed (P=0.046), and that the individuals with genotype II exhibited the shortest body length, suggesting that the 16-bp indel significantly affected growth traits. These findings could extend the spectrum of genetic variations of the ZNF132 gene and provide a valuable theoretical basis via indel markers for marker-assisted selection (MAS) in goat breeding and genetics.
引用
收藏
页码：1813 / 1818
页数：6
相关论文
共 27 条
[21]   Novel polymorphisms of SIX4 gene and their association with body measurement traits in Qinchuan cattle [J].
Wang, Guoqing ;
Zhang, Song ;
Wei, Shengjuan ;
Zhang, Yaran ;
Li, Yaokun ;
Fu, Changzhen ;
Zhao, Chunping ;
Zan, Linsen .
GENE, 2014, 539 (01) :107-110
[22]   Determination of the novel genetic variants of goat STAT5A gene and their effects on body measurement traits in two Chinese native breeds [J].
Wu, Xianfeng ;
Jia, Wenchao ;
Zhang, Jingjing ;
Li, Xiangcheng ;
Pan, Chuanying ;
Lei, Chuzhao ;
Chen, Hong ;
Dang, Ruihua ;
Lan, Xianyong .
SMALL RUMINANT RESEARCH, 2014, 121 (2-3) :232-243
[23]   Identification of a 13 bp indel polymorphism in the 3′-UTR of DGAT2 gene associated with backfat thickness and lean percentage in pigs [J].
Zang, Li ;
Wang, Yuding ;
Sun, Boxing ;
Zhang, Xu ;
Yang, Chunhong ;
Kang, Li ;
Zhao, Zhihui ;
Jiang, Yunliang .
GENE, 2016, 576 (02) :729-733
[24]   Polymorphisms of myostatin gene (MSTN) in four goat breeds and their effects on Boer goat growth performance [J].
Zhang, Chunyan ;
Liu, Yun ;
Xu, Deqing ;
Wen, Qunying ;
Li, Xiang ;
Zhang, Wenmin ;
Yang, Liguo .
MOLECULAR BIOLOGY REPORTS, 2012, 39 (03) :3081-3087
[25]   Developmental validation of an X-Insertion/Deletion polymorphism panel and application in HAN population of China [J].
Zhang, Suhua ;
Sun, Kuan ;
Bian, Yingnan ;
Zhao, Qi ;
Wang, Zheng ;
Ji, Chaoneng ;
Li, Chengtao .
SCIENTIFIC REPORTS, 2015, 5
[26]   SIFT-based local spectrogram image descriptor: a novel feature for robust music identification [J].
Zhang, Xiu ;
Zhu, Bilei ;
Li, Linwei ;
Li, Wei ;
Li, Xiaoqiang ;
Wang, Wei ;
Lu, Peizhong ;
Zhang, Wenqiang .
EURASIP JOURNAL ON AUDIO SPEECH AND MUSIC PROCESSING, 2015,
[27]   Genetic variants and effects on milk traits of the caprine paired-like homeodomain transcription factor 2 (PITX2) gene in dairy goats [J].
Zhao, Haiyu ;
Wu, Xianfeng ;
Cai, Hanfang ;
Pan, Chuanying ;
Lei, Chuzhao ;
Chen, Hong ;
Lan, Xianyong .
GENE, 2013, 532 (02) :203-210
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