A Nanoscale Adhesion Layer to Promote Cell Attachment on PEEK

被引：53

作者：

Dennes, T. Joseph ^{[1
]}

Schwartz, Jeffrey ^{[1
]}

机构：

[1] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 10期

基金：

美国国家科学基金会;

关键词：

IMPLANT MATERIALS; SURFACE; MONOLAYERS;

D O I：

10.1021/ja810075c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel adhesion Layer is described that enables covalent attachment of cell adherent molecules to the surfaces of poly(ethylene terephthalate) (PET) and poly(aryl-ether-ether-ketone) PEEK. Vapor of zirconium or titanium tetra (tert-butoxides) can be deposited on the surface of PET or PEEK at room temperature at a pressure of ca. 10(-3) mm Hg. The thickness of this layer can be controlled by exposure time and monitored by quartz crystal microgravimetry on a surrogate substrate. Controlled thermolysis of the deposited alkoxide gives the metal a mixed oxide-alkoxide layer, which reacts with solutions of phosphonic acids to attach monolayer films of phosphonates, several of which are shown to significantly enhance cell growth compared with the untreated surface.

引用

页码：3456 / +

页数：3

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