Pseudomonas aeruginosa: arsenal of resistance mechanisms, decades of changing resistance profiles, and future antimicrobial therapies

被引：114

作者：

El Zowalaty, Mohamed E. ^{[1
,2
]}

Al Thani, Asmaa A. ^{[2
,3
]}

Webster, Thomas J. ^{[4
,5
]}

El Zowalaty, Ahmed E. ^{[6
,7
]}

Schweizer, Herbert P. ^{[8
,9
]}

Nasrallah, Gheyath K. ^{[2
,3
]}

Marei, Hany E. ^{[2
]}

Ashour, Hossam M. ^{[10
,11
]}

机构：

[1] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA

[2] Qatar Univ, Biomed Res Ctr, Doha, Qatar

[3] Qatar Univ, Coll Arts & Sci, Dept Hlth Sci, Doha 2713, Qatar

[4] Northeastern Univ, Dept Chem Engn, Boston, MA 02018 USA

[5] King Abdulaziz Univ, Ctr Excellence Adv Mat Res, Jeddah 21413, Saudi Arabia

[6] Univ Georgia, Coll Vet Med, Dept Physiol & Pharmacol, Athens, GA 30602 USA

[7] Univ Georgia, Interdisciplinary Toxicol Program, Athens, GA 30602 USA

[8] Univ Florida, Coll Med, Dept Mol Genet & Microbiol, Gainesville, FL 32611 USA

[9] Univ Florida, Emerging Pathogens Inst, Inst Therapeut Innovat, Gainesville, FL 32611 USA

[10] Cairo Univ, Dept Microbiol & Immunol, Fac Pharm, Cairo, Egypt

[11] Wayne State Univ, Dept Pharm Practice, Eugene Applebaum Coll Pharm & Hlth Sci, Detroit, MI USA

来源：

FUTURE MICROBIOLOGY | 2015年 / 10卷 / 10期

关键词：

Pseudomonas aeruginosa; antibiotics; antimicrobial; -lactamases; carbapenemases; decoys; efflux; gold; impermeability; mechanisms; multidrug; nanoantimicrobial; nanoparticles; nanostars; pandrug; phage therapy; pumps; resistance; polymersomes; vaccines; vecoys; virus; BLOOD-STREAM INFECTIONS; GRAM-NEGATIVE BACILLI; INTENSIVE-CARE UNITS; MULTIDRUG EFFLUX SYSTEM; IN-VITRO ACTIVITY; ANTIBIOTIC-RESISTANCE; CYSTIC-FIBROSIS; AMINOGLYCOSIDE RESISTANCE; SUSCEPTIBILITY PATTERNS; SILVER NANOPARTICLES;

D O I：

10.2217/fmb.15.48

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antimicrobial resistance is one of the most serious public health issues facing humans since the discovery of antimicrobial agents. The frequent, prolonged, and uncontrolled use of antimicrobial agents are major factors in the emergence of antimicrobial-resistant bacterial strains, including multidrug-resistant variants. Pseudomonas aeruginosa is a leading cause of nosocomial infections. The abundant data on the increased resistance to antipseudomonal agents support the need for global action. There is a paucity of new classes of antibiotics active against P. aeruginosa. Here, we discuss recent antibacterial resistance profiles and mechanisms of resistance by P. aeruginosa. We also review future potential methods for controlling antibiotic-resistant bacteria, such as phage therapy, nanotechnology and antipseudomonal vaccines.

引用

页码：1683 / 1706

页数：24

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