The Physiopathological Role of IL-33: New Highlights in Bone Biology and a Proposed Role in Periodontal Disease

被引：22

作者：

Cordero da Luz, Felipe Andres ^{[1
]}

Lima Oliveira, Ana Paula ^{[1
]}

Borges, Daniella ^{[2
]}

Brigido, Paula Cristina ^{[1
]}

Barbosa Silva, Marcelo Jose ^{[1
]}

机构：

[1] Univ Fed Uberlandia, Lab Immunoparasitol, Inst Biomed Sci, BR-38400902 Uberlandia, MG, Brazil

[2] Univ Fed Uberlandia, Inst Biomed Sci, BR-38400902 Uberlandia, MG, Brazil

来源：

MEDIATORS OF INFLAMMATION | 2014年 / 2014卷

关键词：

MAST-CELL DEGRANULATION; HUMAN BASOPHILS; INTERLEUKIN-33; ST2; OSTEOCLAST; EXPRESSION; CYTOKINE; DIFFERENTIATION; OSTEOBLASTS; LYMPHOCYTES;

D O I：

10.1155/2014/342410

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Interleukin-33 (IL-33) is a recently described member of the IL-1 family. IL-33 acts as an alarmin, chemoattractant, and nuclear factor. ST2, a member of the Toll-like receptor/IL-1R superfamily, the receptor of IL-33, triggers a plethora of downstream effectors and leads the activation of NFK-B, leading the expression of several genes. IL-33 and ST2 are expressed in the majority of cell types, and the IL-33/ST2 axis has a role in immune response, bone homeostasis, and osteoclastogenesis. Several studies show opposite roles of IL-33 in osteoclastogenesis and the implication in bone biology. Few works studied the role of IL-33 in periodontal disease, but we hypothesize a possible role of IL-33 in periodontal disease and bone loss.

引用

页数：8

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