Novel chiral thioureas for highly enantioselective Michael reactions of malonates to nitroalkenes

被引：5
|
作者：
Yan, Li Jun [1 ]
Liu, Quan Zhong [1 ]
Wang, Xue Lian [1 ]
机构：
[1] China W Normal Univ, Coll Chem & Chem Engn, Lab Appl Chem & Pollut Control Technol, Nanchang 637002, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2009年 / 20卷 / 03期
关键词：
Michael addition; Thiourea; Enantioselectivities; Nitroalkene and malonate; ASYMMETRIC CATALYSIS; CONJUGATE ADDITION; ORGANOCATALYSIS; NITROOLEFINS; KETONES; DONORS;
D O I：
10.1016/j.cclet.2008.11.021
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Highly efficient Michael addition reactions of malonates to nitroalkenes catalyzed by novel chiral thioureas derived from optically pure BINOL and amino acids are reported. Various trans-nitroalkenes reacted with malonates affording the desired products in up to 95% yield with excellent enantioselectivities (up to 97% ee). (C) 2008 Quan Zhong Liu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
引用
收藏
页码：310 / 313
页数：4
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