Synthesis of propane-2,3-diol combinatorial monomers

被引：27

作者：

Acevedo, OL

Andrews, RS

机构：

[1] Isis Pharmaceutical, Carlsbad, CA 92008

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 23期

关键词：

D O I：

10.1016/0040-4039(96)00745-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Base catalyzed reaction of heterocyclic bases with R-(+)-glycidol gives heteroarylpropane-2,3-diols which are functionalized to the 3-O-dimethoxytrityl-2-O-phosphoramidites. A dimethoxytrityl-glycidol is reacted with alkyl or aryl Grignard reagents and then phosphitylated to yield 1-O-dimethoxytrityl-2-phosphoramidites. These compounds can be used for combinatorial oligomer synthesis. (C) 1996 Elsevier Science Ltd

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页码：3931 / 3934

页数：4

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