Should We Consider Des-Acyl Ghrelin as a Separate Hormone and If So, What Does It Do?

被引：66

作者：

Delhanty, Patric J. D. ^{[1
]}

Neggers, Sebastian J. ^{[1
]}

van der Lely, Aart J. ^{[1
]}

机构：

[1] Erasmus MC, Dept Internal Med, NL-3000 CA Rotterdam, Netherlands

来源：

HOW GUT AND BRAIN CONTROL METABOLISM | 2014年 / 42卷

关键词：

O-ACYLTRANSFERASE GOAT; UNACYLATED GHRELIN; INSULIN SENSITIVITY; NONACYLATED GHRELIN; DESACYL GHRELIN; RECEPTOR; PEPTIDE; GLUCOSE; HYPERPHAGIA; EXPRESSION;

D O I：

10.1159/000358345

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The peptides ghrelin (or acyl ghrelin; AG), des-acyl ghrelin (DAG) and obestatin are all encoded by the prepro-ghrelin gene that is expressed predominantly in the stomach. Compared with ghrelin and obestatin, DAG has not received a great amount of attention. DAG has long been considered an inert degradation product of AG. Recent evidence, however, indicates that DAG behaves like a separate hormone. Therefore, it is believed that DAG must activate its own receptor, and that it may also interact with AG at this receptor. DAG can act together with AG, can antagonize AG and seems to have AG-independent effects. Of potential clinical importance is that an increasing number of studies suggest that DAG is a functional inhibitor of AG. Therefore, DAG or DAG analogs are being trialed in early clinical studies for treatment of metabolic disorders such as diabetes, obesity and Prader-Willi syndrome. (C) 2014 S. Karger AG, Basel

引用

页码：163 / 174

页数：12

共 47 条

[11] Unacylated Ghrelin Rapidly Modulates Lipogenic and Insulin Signaling Pathway Gene Expression in Metabolically Active Tissues of GHSR Deleted Mice [J].

Delhanty, Patric J. D. ;

Sun, Yuxiang ;

Visser, Jenny A. ;

van Kerkwijk, Anke ;

Huisman, Martin ;

van IJcken, Wilfred F. J. ;

Swagemakers, Sigrid ;

Smith, Roy G. ;

Themmen, Axel P. N. ;

van der Lely, Aart-Jan .

PLOS ONE, 2010, 5 (07)

[12] Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity [J].

Gauna, C ;

Meyler, FM ;

Janssen, JAMJL ;

Delhanty, PJD ;

Abribat, T ;

Van Koetsveld, P ;

Hofland, LJ ;

Broglio, F ;

Ghigo, E ;

van der Lely, AJ .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (10) :5035-5042

[13] Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes [J].

Gauna, C ;

Delhanty, PJD ;

Hofland, LJ ;

Janssen, JAMJL ;

Broglio, F ;

Ross, RJM ;

Ghigo, E ;

van der Lely, AJ .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (02) :1055-1060

[14] Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type. la and the corticotropin releasing factor 2 receptor [J].

Gauna, Carlotta ;

Delhanty, Patric J. D. ;

van Aken, Maarten O. ;

Janssen, Joop A. M. J. L. ;

Themmen, Axel P. N. ;

Hofland, Leo J. ;

Culler, Michael ;

Broglio, Fabio ;

Ghigo, Ezio ;

van der Lely, Aart Jan .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2006, 251 (1-2) :103-111

[15] Appetite hormones and the transition to hyperphagia in children with Prader-Willi syndrome [J].

Goldstone, A. P. ;

Holland, A. J. ;

Butler, J. V. ;

Whittington, J. E. .

INTERNATIONAL JOURNAL OF OBESITY, 2012, 36 (12) :1564-1570

[16] Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic β-cells and human islets:: Involvement of 3′,5′-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-kinase/Akt signaling [J].

Granata, Riccarda ;

Settanni, Fabio ;

Biancone, Luigi ;

Trovato, Letizia ;

Nano, Rita ;

Bertuzzi, Federico ;

Destefanis, Silvia ;

Annunziata, Marta ;

Martinetti, Monica ;

Catapano, Filomena ;

Ghe, Corrado ;

Isgaard, Jorgen ;

Papotti, Mauro ;

Ghigo, Ezio ;

Muccioli, Giampiero .

ENDOCRINOLOGY, 2007, 148 (02) :512-529

[17] Ghrelin octanoylation mediated by an orphan lipid transferase [J].

Gutierrez, Jesus A. ;

Solenberg, Patricia J. ;

Perkins, Douglas R. ;

Willency, Jill A. ;

Knierman, Michael D. ;

Jin, Zhaoyan ;

Witcher, Derrick R. ;

Luo, Shuang ;

Onyia, Jude E. ;

Hale, John E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (17) :6320-6325

[18] A novel growth hormone secretagogue-1a receptor antagonist that blocks ghrelin-induced growth hormone secretion but induces increased body weight gain [J].

Halem, HA ;

Taylor, JE ;

Dong, JZ ;

Shen, Y ;

Datta, R ;

Abizaid, A ;

Diano, S ;

Horvath, TL ;

Culler, MD .

NEUROENDOCRINOLOGY, 2005, 81 (05) :339-349

[19] Desacyl ghrelin inhibits the orexigenic effect of peripherally injected ghrelin in rats [J].

Inhoff, Tobias ;

Moennikes, Hubert ;

Noetzel, Steffen ;

Stengel, Andreas ;

Goebel, Miriam ;

Dinh, Q. Thai ;

Riedl, Andrea ;

Bannert, Norbert ;

Wisser, Anna-Sophia ;

Wiedenmann, Bertram ;

Klapp, Burghard F. ;

Tache, Yvette ;

Kobelt, Peter .

PEPTIDES, 2008, 29 (12) :2159-2168

[20] Mouse ghrelin-O-acyltransferase (GOAT) plays a critical role in bile acid reabsorption [J].

Kang, Kihwa ;

Schmahl, Jennifer ;

Lee, Jong-Min ;

Garcia, Karen ;

Patil, Ketan ;

Chen, Amelia ;

Keene, Michelle ;

Murphy, Andrew ;

Sleeman, Mark W. .

FASEB JOURNAL, 2012, 26 (01) :259-271

← 1 2 3 4 5 →