Should We Consider Des-Acyl Ghrelin as a Separate Hormone and If So, What Does It Do?

被引：66

作者：

Delhanty, Patric J. D. ^{[1
]}

Neggers, Sebastian J. ^{[1
]}

van der Lely, Aart J. ^{[1
]}

机构：

[1] Erasmus MC, Dept Internal Med, NL-3000 CA Rotterdam, Netherlands

来源：

HOW GUT AND BRAIN CONTROL METABOLISM | 2014年 / 42卷

关键词：

O-ACYLTRANSFERASE GOAT; UNACYLATED GHRELIN; INSULIN SENSITIVITY; NONACYLATED GHRELIN; DESACYL GHRELIN; RECEPTOR; PEPTIDE; GLUCOSE; HYPERPHAGIA; EXPRESSION;

D O I：

10.1159/000358345

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The peptides ghrelin (or acyl ghrelin; AG), des-acyl ghrelin (DAG) and obestatin are all encoded by the prepro-ghrelin gene that is expressed predominantly in the stomach. Compared with ghrelin and obestatin, DAG has not received a great amount of attention. DAG has long been considered an inert degradation product of AG. Recent evidence, however, indicates that DAG behaves like a separate hormone. Therefore, it is believed that DAG must activate its own receptor, and that it may also interact with AG at this receptor. DAG can act together with AG, can antagonize AG and seems to have AG-independent effects. Of potential clinical importance is that an increasing number of studies suggest that DAG is a functional inhibitor of AG. Therefore, DAG or DAG analogs are being trialed in early clinical studies for treatment of metabolic disorders such as diabetes, obesity and Prader-Willi syndrome. (C) 2014 S. Karger AG, Basel

引用

页码：163 / 174

页数：12

共 47 条

[1] Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin [J].

Asakawa, A ;

Inui, A ;

Fujimiya, M ;

Sakamaki, R ;

Shinfuku, N ;

Ueta, Y ;

Meguid, MM ;

Kasuga, M .

GUT, 2005, 54 (01) :18-24

[2] Acylated and unacylated ghrelin attenuate isoproterenol-induced lipolysis in isolated rat visceral adipocytes through activation of phosphoinositide 3-kinase γ and phosphodiesterase 3B [J].

Baragli, Alessandra ;

Ghe, Corrado ;

Arnoletti, Elisa ;

Granata, Riccarda ;

Ghigo, Ezio ;

Muccioli, Giampiero .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2011, 1811 (06) :386-396

[3] Relationships between desacylated and acylated ghrelin and insulin sensitivity in the metabolic syndrome [J].

Barazzoni, Rocco ;

Zanetti, Michela ;

Ferreira, Clara ;

Vinci, Pierandrea ;

Pirulli, Alessia ;

Mucci, MariaPia ;

Dore, Franca ;

Fonda, Maurizio ;

Ciocchi, Beniamino ;

Cattin, Luigi ;

Guarnieri, Gianfranco .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (10) :3935-3940

[4] Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor [J].

Barnett, Brad P. ;

Hwang, Yousang ;

Taylor, Martin S. ;

Kirchner, Henriette ;

Pfluger, Paul T. ;

Bernard, Vincent ;

Lin, Yu-yi ;

Bowers, Erin M. ;

Mukherjee, Chandrani ;

Song, Woo-Jin ;

Longo, Patti A. ;

Leahy, Daniel J. ;

Hussain, Mehboob A. ;

Tschoep, Matthias H. ;

Boeke, Jef D. ;

Cole, Philip A. .

SCIENCE, 2010, 330 (6011) :1689-1692

[5] Metabolic effects of overnight continuous infusion of unacylated ghrelin in humans [J].

Benso, A. ;

St-Pierre, D. H. ;

Prodam, F. ;

Gramaglia, E. ;

Granata, R. ;

van der Lely, A. J. ;

Ghigo, E. ;

Broglio, F. .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2012, 166 (05) :911-916

[6] A practical guide for the stabilization of acylghrelin in human blood collections [J].

Blatnik, Matthew ;

Soderstrom, Catherine I. .

CLINICAL ENDOCRINOLOGY, 2011, 74 (03) :325-331

[7] Desacyl ghrelin is influenced by changes in insulin concentration during an insulin tolerance test [J].

Blijdorp, K. ;

van der Lely, A. J. ;

van den Heuvel-Eibrink, M. M. ;

Huisman, T. M. ;

Themmen, A. P. N. ;

Delhanty, P. J. D. ;

Neggers, S. J. C. M. M. .

GROWTH HORMONE & IGF RESEARCH, 2013, 23 (05) :193-195

[8] Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans [J].

Broglio, F ;

Gottero, C ;

Prodam, F ;

Gauna, C ;

Muccioli, G ;

Papotti, M ;

Abribat, T ;

Van der Lely, AJ ;

Ghigo, E .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (06) :3062-3065

[9] Unacylated ghrelin is associated with changes in body composition and body fat distribution during long-term exercise intervention [J].

Cederberg, Henna ;

Rajala, Ulla ;

Koivisto, Vesa-Matti ;

Jokelainen, Jari ;

Surcel, Helja-Marja ;

Keinanen-Kiukaanniemi, Sirkka ;

Laakso, Markku .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2011, 165 (02) :243-248

[10] Ghrelin: the differences between acyl- and des-acyl ghrelin [J].

Delhanty, Patric J. D. ;

Neggers, Sebastian J. ;

van der Lely, Aart J. .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2012, 167 (05) :601-608

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