Low Levels of Antiretroviral-Resistant HIV Infection in a Routine Clinic in Cameroon that Uses the World Health Organization (WHO) Public Health Approach to Monitor Antiretroviral Treatment and Adequacy with the WHO Recommendation for Second-Line Treatment

被引：54

作者：

Kouanfack, Charles ^{[3
]}

Montavon, Celine ^{[1
]}

Laurent, Christian ^{[1
]}

Aghokeng, Avelin ^{[2
]}

Kenfack, Alain ^{[3
]}

Bourgeois, Anke ^{[4
]}

Koulla-Shiro, Sinata ^{[3
]}

Mpoudi-Ngole, Eitel ^{[2
]}

Peeters, Martine ^{[1
]}

Delaporte, Eric ^{[1
,4
]}

机构：

[1] Univ Montpellier 1, Inst Rech Dev, UMR 145, F-34394 Montpellier 5, France

[2] IRD, Inst Rech Med & Plantes Med IMPM, CRESAR, Virol Lab, Yaounde, Cameroon

[3] Cent Hosp, Yaounde, Cameroon

[4] CHU Montpellier, Ensemble Solidar Therapeut Hosp Reseau Project, Montpellier, France

来源：

CLINICAL INFECTIOUS DISEASES | 2009年 / 48卷 / 09期

关键词：

THERAPY;

D O I：

10.1086/597779

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A cross-sectional study, performed at a routine human immunodeficiency virus (HIV)/AIDS clinic in Cameroon that uses the World Health Organization public health approach, showed low rates of virological failure and drug resistance at 12 and 24 months after initiation of antiretroviral therapy. Importantly, the cross-sectional study also showed that the World Health Organization recommendation for second-line treatment would be effective in almost all patients with HIV drug resistance mutations.

引用

页码：1318 / 1322

页数：5

共 12 条

[1]

[Anonymous], 2006, ANT THER HIV INF AD

[2] Pharmacy refill adherence compared with CD4 count changes for monitoring HIV-infected adults on antiretroviral therapy [J].

Bisson, Gregory P. ;

Gross, Robert ;

Bellamy, Scarlett ;

Chittams, Jesse ;

Hislop, Michael ;

Regensberg, Leon ;

Frank, Ian ;

Maartens, Gary ;

Nachega, Jean B. .

PLOS MEDICINE, 2008, 5 (05) :777-789

[3] The WHO public-health approach to antiretroviral treatment against HIV in resource-limited settings [J].

Gilks, Charles F. ;

Crowley, Siobhan ;

Ekpini, Rene ;

Gove, Sandy ;

Perriens, Jos ;

Souteyrand, Yves ;

Sutherland, Don ;

Vitoria, Marco ;

Guerma, Teguest ;

De Cock, Kevin .

LANCET, 2006, 368 (9534) :505-510

[4]

HOSSEINIPOUR M, 2008, 17 INT AIDS C MEX CI

[5] Evolution of resistance to drugs in HIV-1-infected patients failing antiretroviral therapy [J].

Kantor, R ;

Shafer, RW ;

Follansbee, S ;

Taylor, J ;

Shilane, D ;

Hurley, L ;

Nguyen, DP ;

Katzenstein, D ;

Fessel, WJ .

AIDS, 2004, 18 (11) :1503-1511

[6] Patient retention in antiretroviral therapy programs in sub-Saharan Africa: A systematic review [J].

Rosen, Sydney ;

Fox, Matthew P. ;

Gill, Christopher J. .

PLOS MEDICINE, 2007, 4 (10) :1691-1701

[7] Impact of HIV-1 genetic diversity on plasma HIV-1 RNA quantification -: Usefulness of the Agence Nationale de Recherches sur le SIDA second-generation long terminal repeat-based real-time reverse transcriptase polymerase chain reaction test [J].

Rouet, Francois ;

Chaix, Marie-Laure ;

Nerrienet, Eric ;

Ngo-Giang-Huong, Nicole ;

Plantier, Dean-Christophe ;

Burgard, Marianne ;

Peeters, Martine ;

Damond, Florence ;

Ekouevi, Didier Koumavi ;

Msellati, Philippe ;

Ferradini, Laurent ;

Rukobo, Sandra ;

Marechal, Valerie ;

Schvachsa, Nilda ;

Wakrim, Lahcen ;

Rafalimanana, Christian ;

Rakotoambinina, Benjamin ;

Viard, Jean-Paul ;

Seigneurin, Jean-Marie ;

Rouzioux, Christine .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2007, 45 (04) :380-388

[8] Options for a second-line antiretroviral regimen for HIV type 1-infected patients whose initial regimen of a fixed-dose combination of stavudine, lamivudine, and nevirapine fails [J].

Sungkanuparph, Somnuek ;

Manosuthi, Weerawat ;

Kiertiburanakul, Sasisopin ;

Piyavong, Bucha ;

Chumpathat, Noppanath ;

Chantratita, Wasun .

CLINICAL INFECTIOUS DISEASES, 2007, 44 (03) :447-452

[9] CLUSTAL-W - IMPROVING THE SENSITIVITY OF PROGRESSIVE MULTIPLE SEQUENCE ALIGNMENT THROUGH SEQUENCE WEIGHTING, POSITION-SPECIFIC GAP PENALTIES AND WEIGHT MATRIX CHOICE [J].

THOMPSON, JD ;

HIGGINS, DG ;

GIBSON, TJ .

NUCLEIC ACIDS RESEARCH, 1994, 22 (22) :4673-4680

[10] Biological and genetic characteristics of HIV infections in Cameroon reveals dual group M and O infections and a correlation between SI-inducing phenotype of the predominant CRF02_AG variant and disease stage [J].

Vergne, L ;

Bourgeois, A ;

Mpoudi-Ngole, E ;

Mougnutou, R ;

Mbuagbaw, J ;

Liegeois, F ;

Laurent, C ;

Butel, C ;

Zekeng, L ;

Delaporte, E ;

Peeters, M .

VIROLOGY, 2003, 310 (02) :254-266

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