Well-organized conceptual domains in Alzheimer's disease

被引：42

作者：

Ober, BA

Shenaut, GK

机构：

[1] Univ Calif Davis, Dept Human Genet & Dev, Davis, CA 95616 USA

[2] Dept Vet Affairs Med Ctr, No Calif Hlth Care Syst, Martinez, CA USA

来源：

JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY | 1999年 / 5卷 / 07期

关键词：

Alzheimer's disease; conceptual domains; semantic memory; semantic priming;

D O I：

10.1017/S1355617799577102

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We used a novel apparatus called the Slags board to elicit similarity judgments from 32 Alzheimer's disease (AD) patients and 32 elderly normal (EN) controls for two 12-member conceptual domains, ANIMALS and (musical) INSTRUMENTS. Based on Pathfinder and multidimensional scaling (MDS) analyses, performance by AD patients was nearly identical to that of EN controls for ANIMALS. Performance differed for INSTRUMENTS, but the AD group's Pathfinder network was found to agree with the intuitions of a panel of 18 raters as well as the EN group's. MDS analysis showed no deficit on abstract dimensions for the AD group, for either domain. The results we discussed in the context of degradation I versus preservation of semantic memory in AD.

引用

页码：676 / 684

页数：9

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