Crimean-Congo hemorrhagic fever virus vaccine: past, present, and future

被引:4
作者
Behboudi, Emad [1 ]
Kakavandi, Ehsan [2 ,3 ]
Hamidi-Sofiani, Vahideh [1 ]
Ebrahimian, Arefeh [1 ]
Shayestehpour, Mohammad [4 ,5 ]
机构
[1] Golestan Univ Med Sci, Dept Microbiol, Gorgan, Golestan, Iran
[2] Univ Tehran Med Sci, Sch Publ Hlth, Dept Virol, Tehran, Iran
[3] Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran
[4] Kashan Univ Med Sci, Fac Med, Autoimmune Dis Res Ctr, Kashan, Iran
[5] Kashan Univ Med Sci, Fac Med, Dept Microbiol & Immunol, POB 8715988141,5th Qotb E Ravandi Blvd, Kashan, Iran
来源
REVIEWS AND RESEARCH IN MEDICAL MICROBIOLOGY | 2022年 / 33卷 / 02期
关键词
Crimean-Congo hemorrhagic fever; hemorrhagic fever; vaccine; zoonotic; VESICULAR STOMATITIS-VIRUS; ENCEPHALITIS-VIRUS; IMMUNE-RESPONSE; GLYCOPROTEIN; PATHOGENESIS; INFECTION; EXOSOMES; ANKARA; LETHAL; MICE;
D O I
10.1097/MRM.0000000000000260
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Crimean-Congo hemorrhagic fever (CCHF) has been recognized as a tick-borne infection caused by a member of the Nairoviridae family within the Bunyavirales order, named CCHF virus. CCHF virus is a zoonotic virus, so transferred between vertebrates and humans. Therefore, vaccination in humans and animals might reduce the risk of infection. Currently, there are no globally licensed vaccines or therapeutics for CCHF. Although several studies have been performed on the production of the CCHF vaccine, any of these vaccines were not fully protective. Hence, the development of a new generation of vaccines could contribute to better management of CCHF. In this review, we will discuss on features of these vaccine candidates. Copyright (C) 2021 Wolters Kluwer Health, Inc. All rights reserved.
引用
收藏
页码:109 / 116
页数:8
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