Lessons from ECLIPSE: a review of COPD biomarkers

被引：123

作者：

Faner, Rosa ^{[1
]}

Tal-Singer, Ruth ^{[2
]}

Riley, John H. ^{[3
]}

Celli, Bartolome ^{[4
,5
]}

Vestbo, Jorgen ^{[6
,7
,8
]}

MacNee, William ^{[9
]}

Bakke, Per ^{[10
]}

Calverley, Peter M. A. ^{[11
,12
]}

Coxson, Harvey ^{[13
]}

Crim, Courtney ^{[14
]}

Edwards, Lisa D. ^{[14
]}

Locantore, Nick ^{[14
]}

Lomas, David A. ^{[15
]}

Miller, Bruce E. ^{[2
]}

Rennard, Stephen I. ^{[16
]}

Wouters, Emiel F. M. ^{[17
]}

Yates, Julie C. ^{[14
]}

Silverman, Edwin K.

Agusti, Alvar ^{[1
,18
]}

机构：

[1] Ciber Enfermedades Resp CIBERES, Fundacio Invest Sanitaria Illes Balears FISIB, Barcelona, Catalunya, Spain

[2] GlaxoSmithKline Res & Dev Ltd, King Of Prussia, PA USA

[3] GlaxoSmithKline Res & Dev Ltd, Stevenage, Herts, England

[4] Brigham & Womens Hosp, Network Med & Pulm & Crit Care Div, Channing Div, Boston, MA 02115 USA

[5] Harvard Univ, Sch Med, Boston, MA USA

[6] Univ Southern Denmark, Odense Univ Hosp, Dept Resp Med, Odense, Denmark

[7] Univ Southern Denmark, Inst Clin, Odense, Denmark

[8] Univ Hosp South Manchester NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Resp & Allergy Res Grp, Manchester, Lancs, England

[9] Univ Edinburgh, MRC Ctr Inflammat Res, Queens Med Res Inst, Edinburgh, Midlothian, Scotland

[10] Univ Bergen, Haukeland Univ Hosp, Dept Thorac Med, Inst Clin Sci, Bergen, Norway

[11] Aintree Univ Hosp NHS Fdn Trust, Div Infect, Liverpool L9 7AL, Merseyside, England

[12] Aintree Univ Hosp NHS Fdn Trust, Immun Clin Sci Ctr, Liverpool L9 7AL, Merseyside, England

[13] Univ British Columbia, Vancouver Gen Hosp, Dept Radiol, Vancouver, BC V5Z 1M9, Canada

[14] GlaxoSmithKline Res & Dev Ltd, Res Triangle Pk, NC USA

[15] UCL, Div Med, London, England

[16] Univ Nebraska Med Ctr, Dept Pulm & Crit Care Med, Omaha, NE USA

[17] Maastricht Univ, Med Ctr, Dept Resp Med, Maastricht, Netherlands

[18] Univ Barcelona, Hosp Clin, IDIBAPS, Thorax Inst, Barcelona, Spain

来源：

THORAX | 2014年 / 69卷 / 07期

关键词：

OBSTRUCTIVE PULMONARY-DISEASE; GENOME-WIDE ASSOCIATION; SURFACTANT PROTEIN-D; SYSTEMIC INFLAMMATION; SUSCEPTIBILITY LOCUS; SPUTUM NEUTROPHILS; BLOOD BIOMARKERS; LUNG-FUNCTION; EMPHYSEMA; COHORT;

D O I：

10.1136/thoraxjnl-2013-204778

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) study was a large 3-year observational controlled multicentre international study aimed at defining clinically relevant subtypes of chronic obstructive pulmonary disease (COPD) and identifying novel biomarkers and genetic factors. So far, the ECLIPSE study has produced more than 50 original publications and 75 communications to international meetings, many of which have significantly influenced our understanding of COPD. However, because there is not one paper reporting the biomarker results of the ECLIPSE study that may serve as a reference for practising clinicians, researchers and healthcare providers from academia, industry and government agencies interested in COPD, we decided to write a review summarising the main biomarker findings in ECLIPSE.

引用

页码：666 / 672

页数：7

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