Legionella pneumophila replication vacuole formation involves rapid recruitment of proteins of the early secretory system

被引：170

作者：

Derré, I

Isberg, RR

机构：

[1] Tufts Univ, Sch Med, Dept Mol Biol & Microbiol, Boston, MA 02111 USA

[2] Tufts Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02111 USA

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 05期

关键词：

D O I：

10.1128/IAI.72.5.3048-3053.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Legionella pneumophila vacuole biogenesis was analyzed by using a cell-free system. We show that calnexin, Sec22b, and Rab1 are recruited to the vacuole very shortly after bacterial uptake, and we have identified Rab1 as a potential host factor involved in the endoplasmic reticulum recruitment process.

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页码：3048 / 3053

页数：6

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