Metabolic programming: fetal origins of obesity and metabolic syndrome in the adult

被引：54
作者：
Ismail-Beigi, Faramarz [1 ]
Catalano, Patrick M.
Hanson, Richard W.
机构：
[1] Case Western Reserve Univ, Sch Med, Dept Med, Cleveland Diabet Ctr, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Sch Med, Dept Reprod Biol, Cleveland Diabet Ctr, Cleveland, OH 44106 USA
[3] Case Western Reserve Univ, Sch Med, Dept Biochem, Cleveland Diabet Ctr, Cleveland, OH 44106 USA
来源：
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 2006年 / 291卷 / 03期
关键词：
D O I：
10.1152/ajpendo.00105.2006
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Exposure of the fetus to the intrauterine milieu can have profound effects on the health of the offspring in adulthood. Results of a series of studies demonstrate the powerful influence of the mother's metabolic state on whether the emerging adult develops obesity and hyperinsulinemia. Importantly, these attributes can be passed on to the next generation nongenetically and can be reversed and prevented.
引用
收藏
页码：E439 / E440
页数：2
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