BACE1 interacts with nicastrin

被引：26

作者：

Hattori, C

Asai, M

Oma, Y

Kino, Y

Sasagawa, N

Saido, TC

Maruyama, K

Ishiura, S ^{[1
]}

机构：

[1] Univ Tokyo, Dept Life Sci, Grad Sch Arts & Sci, Meguro Ku, Tokyo 1538902, Japan

[2] RIKEN, Brain Sci Inst, Wako, Saitama 3510198, Japan

[3] Saitama Med Sch, Dept Pharmacol, Moroyama, Saitama 3500495, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2002年 / 293卷 / 04期

关键词：

Alzheimer's disease; APP; A beta; beta-secretase; gamma-secretase; BACE1; nicastrin;

D O I：

10.1016/S0006-291X(02)00351-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

beta-Amyloid peptide (Abeta) is generated through the proteolytic cleavage of beta-amyloid precursor protein (APP) by beta- and gamma-secretases. The beta-secretase, BACE1, initiates Abeta formation followed by gamma-cleavage within the APP transmembrane domain. Although BACE1 localizes in the transGolgi network (TGN), its physiological substrates and modulators are not known, In addition, the relationship to other secretase(s) also remains unidentified. Here, we demonstrate that BACE1 binds to nicastrin, a component of gamma-secretase complexes, in vitro, and that nicastrin activates beta-secretase activity in COS-7 cells. (C) 2002 Elsevier Science (USA). All rights reserved.

引用

页码：1228 / 1232

页数：5

共 50 条

[1] BACE1 interacts with lipid raft proteins.
Hattori, Chinatsu
Asai, Masashi
Onishi, Hayato
Sasagawa, Noboru
Hashimoto, Yasuhiro
Saido, Takaomi C.
Maruyama, Kei
Mizutani, Shigehiko
Ishiura, Shoichi
JOURNAL OF NEUROSCIENCE RESEARCH, 2006, 84 (04) : 912 - 917
[2] Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing
Zhao, Yonghao
Wang, Yunshu
Yang, Jiaye
Wang, Xin
Zhao, Yingjun
Zhang, Xian
Zhang, Yun-wu
MOLECULAR NEURODEGENERATION, 2012, 7
[3] Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing
Yonghao Zhao
Yunshu Wang
Jiaye Yang
Xin Wang
Yingjun Zhao
Xian Zhang
Yun-wu Zhang
Molecular Neurodegeneration, 7
[4] Cognitive deficits in BACE1 knockout but not BACE1 transgenic mice
Harper, A
Dingwall, C
Gonzalez, MI
BEHAVIOURAL PHARMACOLOGY, 2005, 16 : S92 - S93
[5] Clec4g (LSECtin) interacts with BACE1 and suppresses Aβ generation
Kizuka, Yasuhiko
Kitazume, Shinobu
Sato, Keiko
Taniguchi, Naoyuki
FEBS LETTERS, 2015, 589 (13) : 1418 - 1422
[6] Licoflavonol Reduces Aβ Secretion by Increasing BACE1 Phosphorylation to Facilitate BACE1 Degradation
Gu, Ming-Yao
Chun, Yoon Sun
Yong, Ryu Shi
Yang, Hyun Ok
MOLECULAR NUTRITION & FOOD RESEARCH, 2019, 63 (03)
[7] Peptidomimetic Modulators of BACE1
Juliano, John Paul
Small, David H.
Aguilar, Marie-Isabel
AUSTRALIAN JOURNAL OF CHEMISTRY, 2020, 73 (04) : 366 - 376
[8] Amplified voltammetric characterization of cleavage of the biotinylated peptide by BACE1 and screening of BACE1 inhibitors
Yi, Xinyao
Han, Hongxing
Zhang, Yu
Wang, Jianxiu
Zhang, Yi
Zhou, Feimeng
BIOSENSORS & BIOELECTRONICS, 2013, 50 : 224 - 228
[9] BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats
Martin Weber
Tiffany Wu
William J. Meilandt
Sara L. Dominguez
Hilda O. Solanoy
Janice A. Maloney
Hai Ngu
Miriam Baca
Chung Kung
Lisa Lima
Timothy K. Earr
Daniel Fleck
Shannon D. Shields
William F. Forrest
Oded Foreman
Søren Warming
Ryan J. Watts
Kimberly Scearce-Levie
Scientific Reports, 7
[10] Fueling the Alzheimer's BACE1 race with genetic insights and cyclopropyloxazine BACE1 inhibitors
Minatti, Ana
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254

← 1 2 3 4 5 →