Considerations for pre-clinical models and clinical trials of pluripotent stem cell-derived cardiomyocytes

被引：10

作者：

Hulot, Jean-Sebastien ^{[1
,2
]}

Stillitano, Francesca ^{[1
]}

Salem, Joe Elie ^{[2
]}

Kovacic, Jason C. ^{[1
]}

Fuster, Valentin ^{[1
]}

Hajjar, Roger J. ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Cardiovasc Res Ctr, New York, NY 10029 USA

[2] Univ Paris 06, UMRS ICAN Cardiometab & Nutr, UPMC, Paris, France

来源：

STEM CELL RESEARCH & THERAPY | 2014年 / 5卷

关键词：

TRANSPLANTATION THERAPY; DILATED CARDIOMYOPATHY; MYOCARDIAL-INFARCTION; MOUSE HEART; LINES; DIFFERENTIATION; IMMUNOGENICITY; POPULATION; REGENERATION; FIBROBLASTS;

D O I：

10.1186/scrt390

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Pluripotent stem cells (PSCs) represent an appealing source from which to develop cell replacement therapies. Different initiatives have been launched to promote their development toward clinical applications. This article will review the main questions that should be considered before translating PSC-derived cardiomyocytes into clinical investigations, including the development of good manufacturing practice-level PSC lines, the development of efficient protocols to generate pure populations of cardiac myocytes, and the development of techniques to improve the retention and survival rate of transplanted cells.

引用

页数：7

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