hChAT: A Tool for the Chemoenzymatic Generation of Potential Acetyl/Butyrylcholinesterase Inhibitors

被引：18
作者：
Green, Keith D. [1 ,2 ]
Fridman, Micha [3 ]
Garneau-Tsodikova, Sylvie [1 ,2 ]
机构：
[1] Univ Michigan, Coll Pharm, Dept Med Chem, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA
[3] Tel Aviv Univ, Sch Chem, IL-66978 Tel Aviv, Israel
来源：
CHEMBIOCHEM | 2009年 / 10卷 / 13期
关键词：
acylation; Alzheimer's disease; coenzyme A cosubstrates; enzyme promiscuity; inhibitors; CARBAMOYLCHOLINE ANALOGS; CHOLINERGIC HYPOTHESIS; ACETYLTRANSFERASE; ACETYLCHOLINE; MECHANISM;
D O I：
10.1002/cbic.200900309
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
[No abstract available]
引用
收藏
页码：2191 / 2194
页数：4
相关论文
共 23 条
  • [1] THE CHOLINERGIC HYPOTHESIS OF GERIATRIC MEMORY DYSFUNCTION
    BARTUS, RT
    DEAN, RL
    BEER, B
    LIPPA, AS
    [J]. SCIENCE, 1982, 217 (4558) : 408 - 417
  • [2] Rivastigmine for Alzheimer's disease
    Birks, Jacqueline
    Evans, John Grimley
    Iakovidou, Vasso
    Tsolaki, Magda
    Holt, Francesca E.
    [J]. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2009, (02):
  • [3] The place of choline acetyltransferase activity measurement in the "Cholinergic hypothesis" of neurodegenerative diseases
    Contestabile, Antonio
    Ciani, Elisabetta
    Contestabile, Andrea
    [J]. NEUROCHEMICAL RESEARCH, 2008, 33 (02) : 318 - 327
  • [4] Reactivity of trypsin in reverse micelles: neglected role of aggregate size compared to water-pool components
    Dasgupta, A
    Das, D
    Das, PK
    [J]. BIOCHIMIE, 2005, 87 (12) : 1111 - 1119
  • [5] ELWYN D, 1955, J BIOL CHEM, V213, P281
  • [6] Fifer E.K., 2008, FOYES PRINCIPLES MED, P361
  • [7] FLYNN DD, 1995, J NEUROCHEM, V64, P1888
  • [8] Cholinergic function and Alzheimer's disease
    Giacobini, E
    [J]. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2003, 18 : S1 - S5
  • [9] Carbamoylcholine analogs as nicotinic acetylcholine receptor agonists-Structural modifications of 3-(dimethylamino)butyl dimethylcarbamate (DMABC)
    Hansen, Camilla P.
    Jensen, Anders A.
    Balle, Thomas
    Bitsch-Jensen, Klaus
    Hassan, Mohamud M.
    Liljefors, Tommy
    Frolund, Bente
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (01) : 87 - 91
  • [10] Novel Acetylcholine and Carbamoylcholine Analogues: Development of a Functionally Selective α4β2 Nicotinic Acetylcholine Receptor Agonist
    Hansen, Camilla P.
    Jensen, Anders A.
    Christensen, Jeppe K.
    Balle, Thomas
    Lijefors, Tommy
    Frolund, Bente
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (23) : 7380 - 7395
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