Tumour budding with and without admixed inflammation: two different sides of the same coin?

被引：16
作者：
Max, Nicole [1 ]
Harbaum, Lars [2 ]
Pollheimer, Marion J. [1 ]
Lindtner, Richard A. [3 ]
Kornprat, Peter [4 ]
Langner, Cord [1 ]
机构：
[1] Med Univ, Inst Pathol, Auenbruggerpl 25, A-8036 Graz, Austria
[2] Univ Med Ctr Hamburg Eppendorf, BMT Sect Pneumol, Dept Oncol, Haematol,BMT Sect Pneumol, Martinistr 52, D-20246 Hamburg, Germany
[3] Med Univ Innsbruck, Dept Surg, Innrain 52, A-6020 Innsbruck, Austria
[4] Med Univ, Dept Surg, Auenbruggerpl 29, A-8036 Graz, Austria
来源：
BRITISH JOURNAL OF CANCER | 2016年 / 114卷 / 04期
关键词：
colorectal cancer; tumour budding; inflammation; prognosis; survival; multivariate logistic regression; epithelial-mesenchymal transition; II COLORECTAL-CANCER; CARCINOMA; MARKER; INDEX;
D O I：
10.1038/bjc.2015.454
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: Tumour budding is an adverse prognostic indicator in colorectal cancer (CRC). Marked overall peritumoural inflammation has been associated with favourable outcome and may lead to the presence of isolated cancer cells due to destruction of invading cancer cell islets. Methods: We assessed the prognostic significance of tumour budding and peritumoural inflammation in a cohort of 381 patients with CRC applying univariate and multivariate analyses. Results: Patients with high-grade budding and marked inflammation had a significantly better outcome compared with patients with high-grade budding and only mild inflammation. Outcome in these cases, however, was still worse compared with cases with low-grade budding, in which the extent of peritumoural inflammation had no further prognostic effect. Conclusions: Tumour budding proved to be a powerful prognostic variable in patients with CRC. Scattering of invading cancer cell islets by marked overall peritumoural inflammation seems to have a minor role.
引用
收藏
页码：368 / 371
页数：4
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    Mirabelli, Peppino
    Paciolla, Mariateresa
    Esposito, Elio
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    Ursini, Matilde Valeria
    [J]. INTERNATIONAL REVIEWS OF IMMUNOLOGY, 2015, 34 (06) : 445 - 459
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    [J]. MOLECULES, 2020, 25 (10):
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    Biagini, Andrea
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    [J]. AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2006, 126 (04) : 494 - 502
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