Tumour budding with and without admixed inflammation: two different sides of the same coin?

被引：16
作者：
Max, Nicole [1 ]
Harbaum, Lars [2 ]
Pollheimer, Marion J. [1 ]
Lindtner, Richard A. [3 ]
Kornprat, Peter [4 ]
Langner, Cord [1 ]
机构：
[1] Med Univ, Inst Pathol, Auenbruggerpl 25, A-8036 Graz, Austria
[2] Univ Med Ctr Hamburg Eppendorf, BMT Sect Pneumol, Dept Oncol, Haematol,BMT Sect Pneumol, Martinistr 52, D-20246 Hamburg, Germany
[3] Med Univ Innsbruck, Dept Surg, Innrain 52, A-6020 Innsbruck, Austria
[4] Med Univ, Dept Surg, Auenbruggerpl 29, A-8036 Graz, Austria
来源：
BRITISH JOURNAL OF CANCER | 2016年 / 114卷 / 04期
关键词：
colorectal cancer; tumour budding; inflammation; prognosis; survival; multivariate logistic regression; epithelial-mesenchymal transition; II COLORECTAL-CANCER; CARCINOMA; MARKER; INDEX;
D O I：
10.1038/bjc.2015.454
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: Tumour budding is an adverse prognostic indicator in colorectal cancer (CRC). Marked overall peritumoural inflammation has been associated with favourable outcome and may lead to the presence of isolated cancer cells due to destruction of invading cancer cell islets. Methods: We assessed the prognostic significance of tumour budding and peritumoural inflammation in a cohort of 381 patients with CRC applying univariate and multivariate analyses. Results: Patients with high-grade budding and marked inflammation had a significantly better outcome compared with patients with high-grade budding and only mild inflammation. Outcome in these cases, however, was still worse compared with cases with low-grade budding, in which the extent of peritumoural inflammation had no further prognostic effect. Conclusions: Tumour budding proved to be a powerful prognostic variable in patients with CRC. Scattering of invading cancer cell islets by marked overall peritumoural inflammation seems to have a minor role.
引用
收藏
页码：368 / 371
页数：4
相关论文
共 47 条
  • [31] Preoperative and early postoperative seizures in patients with glioblastoma-two sides of the same coin?
    Ahmadipour, Yahya
    Rauschenbach, Laurel
    Santos, Alejandro
    Oppong, Marvin Darkwah
    Lazaridis, Lazaros
    Quesada, Carlos M.
    Junker, Andreas
    Pierscianek, Daniela
    Dammann, Philipp
    Wrede, Karsten H.
    Scheffler, Bjoern
    Glas, Martin
    Stuschke, Martin
    Sure, Ulrich
    Jabbarli, Ramazan
    NEURO-ONCOLOGY ADVANCES, 2021, 3 (01)
  • [32] Stereotactic body radiation therapy and surgery for early lung cancer "two sides of the same coin"
    Parisi, Giuseppe
    Ceschia, Tino
    Parisi, Alessandro
    JOURNAL OF THORACIC DISEASE, 2019, 11 : S271 - S274
  • [33] Chronic Rejection and Atherosclerosis in Post-Transplant Cardiovascular Mortality: Two Sides of the Same Coin
    Otunla, Afolarin A.
    Shanmugarajah, Kumaran
    Madariaga, Maria Lucia
    Davies, Alun H.
    Shalhoub, Joseph
    HEART LUNG AND CIRCULATION, 2022, 31 (02) : 162 - 166
  • [34] Rituximab treatment of systemic lupus erythematosus in controlled trials and in clinical practice: Two sides of the same coin
    Conti, Fabrizio
    Perricone, Carlo
    Ceccarelli, Fulvia
    Valesini, Guido
    AUTOIMMUNITY REVIEWS, 2010, 9 (11) : 716 - 720
  • [35] EMT/MET plasticity in cancer and Go-or-Grow decisions in quiescence: the two sides of the same coin?
    Akhmetkaliyev, Azamat
    Alibrahim, Noura
    Shafiee, Darya
    Tulchinsky, Eugene
    MOLECULAR CANCER, 2023, 22 (01)
  • [36] Two Sides of the Same Coin: Pediatric-Onset and Adult-Onset Common Variable Immune Deficiency
    Lauren A. Sanchez
    Solrun Melkorka Maggadottir
    Matthew S. Pantell
    Patricia Lugar
    Charlotte Cunningham Rundles
    Kathleen E. Sullivan
    Journal of Clinical Immunology, 2017, 37 : 592 - 602
  • [37] Two Sides of the Same Coin: Pediatric-Onset and Adult-Onset Common Variable Immune Deficiency
    Sanchez, Lauren A.
    Maggadottir, Solrun Melkorka
    Pantell, Matthew S.
    Lugar, Patricia
    Rundles, Charlotte Cunningham
    Sullivan, Kathleen E.
    JOURNAL OF CLINICAL IMMUNOLOGY, 2017, 37 (06) : 592 - 602
  • [38] Novel insights into the genetically obese (ob/ob) and diabetic (db/db) mice: two sides of the same coin
    Suriano, Franc
    Vieira-Silva, Sara
    Falony, Gwen
    Roumain, Martin
    Paquot, Adrien
    Pelicaen, Rudy
    Regnier, Marion
    Delzenne, Nathalie M.
    Raes, Jeroen
    Muccioli, Giulio G.
    Van Hul, Matthias
    Cani, Patrice D.
    MICROBIOME, 2021, 9 (01)
  • [39] Optimizing Loco Regional Management of Oligometastatic Colorectal Cancer: Technical Aspects and Biomarkers, Two Sides of the Same Coin
    Mauri, Giovanni
    Monfardini, Lorenzo
    Garnero, Andrea
    Zampino, Maria Giulia
    Orsi, Franco
    Della Vigna, Paolo
    Bonomo, Guido
    Varano, Gianluca Maria
    Busso, Marco
    Gazzera, Carlo
    Fonio, Paolo
    Veltri, Andrea
    Calandri, Marco
    CANCERS, 2021, 13 (11)
  • [40] Two Sides of the Same Coin: ERP and Wavelet Analyses of Visual Potentials Evoked and Induced by Task-Relevant Faces
    Van der Lubbe, Rob H. J.
    Szumska, Izabela
    Fajkowska, Malgorzata
    ADVANCES IN COGNITIVE PSYCHOLOGY, 2016, 12 (04) : 153 - 167
12345