Promoter variation in the catechol-O-methyltransferase gene is associated with remission of symptoms during fluvoxamine treatment for major depression

被引：5
|
作者：
Fukui, Naoki [1 ]
Suzuki, Yutaro [1 ]
Sugai, Takuro [1 ]
Watanabe, Junzo [1 ]
Ono, Shin [1 ]
Tsuneyama, Nobuto [1 ]
Someya, Toshiyuki [1 ]
机构：
[1] Niigata Univ, Dept Psychiat, Grad Sch Med & Dent Sci, Niigata, Japan
来源：
PSYCHIATRY RESEARCH | 2014年 / 218卷 / 03期
关键词：
COMT; Depression; Fluvoxamine; VAL(108/158)MET POLYMORPHISM; TREATMENT RESPONSE; PAROXETINE; SEVERITY; PLACEBO; COMT;
D O I：
10.1016/j.psychres.2014.04.030
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
We investigated the association between remission of depressive symptoms in fluvoxamine treatment and catechol-O-methyltransferase (COMT) gene. Sixteen SNPs in the COMT gene were investigated in 123 outpatients with major depression. Three single nucleotide polymorphisms located in the 5' region were associated with remission in fluvoxamine-treated outpatients with moderate to severe depression. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：353 / 355
页数：3
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