RAB7 Controls Melanoma Progression by Exploiting a Lineage-Specific Wiring of the Endolysosomal Pathway

被引：83

作者：

Alonso-Curbelo, Direna ^{[1
]}

Riveiro-Falkenbach, Erica ^{[1
]}

Perez-Guijarro, Eva ^{[1
]}

Cifdaloz, Metehan ^{[1
]}

Karras, Panagiotis ^{[1
]}

Osterloh, Lisa ^{[1
]}

Megias, Diego ^{[2
]}

Canon, Estela ^{[1
]}

Calvo, Tonantzin G. ^{[1
]}

Olmeda, David ^{[1
]}

Gomez-Lopez, Gonzalo ^{[3
]}

Grana, Osvaldo ^{[3
]}

Sanchez-Arevalo Lobo, Victor Javier ^{[4
]}

Pisano, David G. ^{[3
]}

Wang, Hao-Wei ^{[5
]}

Ortiz-Romero, Pablo ^{[6
]}

Tormo, Damia ^{[1
]}

Hoek, Keith ^{[7
]}

Rodriguez-Peralto, Jose L. ^{[6
]}

Joyce, Johanna A. ^{[5
]}

Soengas, Maria S. ^{[1
]}

机构：

[1] Spanish Natl Canc Res Ctr CNIO, Mol Oncol Programme, Melanoma Lab, Madrid 28029, Spain

[2] Spanish Natl Canc Res Ctr CNIO, Confocal Microscopy Unit, Biotechnol Programme, Madrid 28029, Spain

[3] Spanish Natl Canc Res Ctr CNIO, Struct Biol & Biocomp Programme, Bioinformat Unit, Madrid 28029, Spain

[4] Spanish Natl Canc Res Ctr CNIO, Mol Pathol Programme, Epithelial Carcinogenesis Lab, Madrid 28029, Spain

[5] Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10065 USA

[6] Univ Complutense, Hosp 12 Octubre, Inst Invest I 12, Madrid 28041, Spain

[7] Univ Zurich Hosp, Dept Dermatol, CH-8091 Zurich, Switzerland

来源：

CANCER CELL | 2014年 / 26卷 / 01期

关键词：

MITF TRANSCRIPTION FACTORS; MALIGNANT-MELANOMA; GENE-EXPRESSION; CANCER; CELLS; PROTEIN; DISEASE; TRAFFICKING; SURVIVAL; METASTASIS;

D O I：

10.1016/j.ccr.2014.04.030

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although common cancer hallmarks are well established, lineage-restricted oncogenes remain less understood. Here, we report an inherent dependency of melanoma cells on the small GTPase RAB7, identified within a lysosomal gene cluster that distinguishes this malignancy from over 35 tumor types. Analyses in human cells, clinical specimens, and mouse models demonstrated that RAB7 is an early-induced melanoma driver whose levels can be tuned to favor tumor invasion, ultimately defining metastatic risk. Importantly, RAB7 levels and function were independent of MITF, the best-characterized melanocyte lineage-specific transcription factor. Instead, we describe the neuroectodermal master modulator SOX10 and the oncogene MYC as RAB7 regulators. These results reveal a unique wiring of the lysosomal pathway that melanomas exploit to foster tumor progression.

引用

页码：61 / 76

页数：16

共 48 条

[1] An Integrated Approach to Uncover Drivers of Cancer [J].

Akavia, Uri David ;

Litvin, Oren ;

Kim, Jessica ;

Sanchez-Garcia, Felix ;

Kotliar, Dylan ;

Causton, Helen C. ;

Pochanard, Panisa ;

Mozes, Eyal ;

Garraway, Levi A. ;

Pe'er, Dana .

CELL, 2010, 143 (06) :1005-1017

[2] A high-throughput study in melanoma identifies epithelial-mesenchymal transition as a major determinant of metastasis [J].

Alonso, Soledad R. ;

Tracey, Lorraine ;

Ortiz, Pablo ;

Perez-Gomez, Beatriz ;

Palacios, Jose ;

Pollan, Marina ;

Linares, Juan ;

Serrano, Salvio ;

Saez-Castillo, Ana I. ;

Sanchez, Lydia ;

Pajares, Raquel ;

Sanchez-Aguilera, Abel ;

Artiga, Maria J. ;

Piris, Miguel A. ;

Rodriguez-Peralto, Jose L. .

CANCER RESEARCH, 2007, 67 (07) :3450-3460

[3] The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity [J].

Barretina, Jordi ;

Caponigro, Giordano ;

Stransky, Nicolas ;

Venkatesan, Kavitha ;

Margolin, Adam A. ;

Kim, Sungjoon ;

Wilson, Christopher J. ;

Lehar, Joseph ;

Kryukov, Gregory V. ;

Sonkin, Dmitriy ;

Reddy, Anupama ;

Liu, Manway ;

Murray, Lauren ;

Berger, Michael F. ;

Monahan, John E. ;

Morais, Paula ;

Meltzer, Jodi ;

Korejwa, Adam ;

Jane-Valbuena, Judit ;

Mapa, Felipa A. ;

Thibault, Joseph ;

Bric-Furlong, Eva ;

Raman, Pichai ;

Shipway, Aaron ;

Engels, Ingo H. ;

Cheng, Jill ;

Yu, Guoying K. ;

Yu, Jianjun ;

Aspesi, Peter, Jr. ;

de Silva, Melanie ;

Jagtap, Kalpana ;

Jones, Michael D. ;

Wang, Li ;

Hatton, Charles ;

Palescandolo, Emanuele ;

Gupta, Supriya ;

Mahan, Scott ;

Sougnez, Carrie ;

Onofrio, Robert C. ;

Liefeld, Ted ;

MacConaill, Laura ;

Winckler, Wendy ;

Reich, Michael ;

Li, Nanxin ;

Mesirov, Jill P. ;

Gabriel, Stacey B. ;

Getz, Gad ;

Ardlie, Kristin ;

Chan, Vivien ;

Myer, Vic E. .

NATURE, 2012, 483 (7391) :603-607

[4] The three M's: melanoma, microphthalmia-associated transcription factor and microRNA [J].

Bell, Rachel E. ;

Levy, Carmit .

PIGMENT CELL & MELANOMA RESEARCH, 2011, 24 (06) :1088-1106

[5] Rab7: A key to lysosome biogenesis [J].

Bucci, C ;

Thomsen, P ;

Nicoziani, P ;

McCarthy, J ;

van Deurs, B .

MOLECULAR BIOLOGY OF THE CELL, 2000, 11 (02) :467-480

[6] A Switch in the Expression of Embryonic EMT-Inducers Drives the Development of Malignant Melanoma [J].

Caramel, Julie ;

Papadogeorgakis, Eftychios ;

Hill, Louise ;

Browne, Gareth J. ;

Richard, Geoffrey ;

Wierinckx, Anne ;

Saldanha, Gerald ;

Osborne, Joy ;

Hutchinson, Peter ;

Tse, Gina ;

Lachuer, Joel ;

Puisieux, Alain ;

Pringle, J. Howard ;

Ansieau, Stephane ;

Tulchinsky, Eugene .

CANCER CELL, 2013, 24 (04) :466-480

[7] The gluttonous side of malignant melanoma: basic and clinical implications of macroautophagy [J].

Checinska, Agnieszka ;

Soengas, Maria S. .

PIGMENT CELL & MELANOMA RESEARCH, 2011, 24 (06) :1116-1132

[8] Fifteen-year quest for microphthalmia-associated transcription factor target genes [J].

Cheli, Yann ;

Ohanna, Mickael ;

Ballotti, Robert ;

Bertolotto, Corine .

PIGMENT CELL & MELANOMA RESEARCH, 2010, 23 (01) :27-40

[9] MYC on the Path to Cancer [J].

Dang, Chi V. .

CELL, 2012, 149 (01) :22-35

[10] The lysosome turns fifty [J].

de Duve, C .

NATURE CELL BIOLOGY, 2005, 7 (09) :847-849

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