11-ketotestosterone potentiates estrogen-induced vitellogenin production in liver of Japanese eel (Anguilla japonica)

被引：6

作者：

Asanuma, H ^{[1
]}

Ohashi, H

Matsubara, H

Ijiri, S

Matsubara, T

Todo, T

Adachi, S

Yamauchi, K

机构：

[1] Hokkaido Univ, Grad Sch Fisheries Sci, Hakodate, Hokkaido 0418611, Japan

[2] Hokkaido Natl Fiesheries Res Inst, Kushiro 0850802, Japan

来源：

FISH PHYSIOLOGY AND BIOCHEMISTRY | 2003年 / 28卷 / 1-4期

关键词：

androgen; estrogen; vitellogenin; hepatocyte;

D O I：

10.1023/B:FISH.0000030599.10456.9c

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Isolated hepatocytes from male Japanese eel at various stages of human chorionic gonadotropin (HCG)-induced spermatogenesis were cultured in the presence of estradiol-17beta (E2). Hepatic vitellogenin (VTG) production in response to E2 increased during testicular development. This indicates that VTG production is influenced by gonadal maturity not only in females but also in males, where serum levels of 11-ketotestosterone (11KT) increase during testicular development. Recently, it has been confirmed that significant levels of 11KT are detected in maturing female eel. Therefore, in a next experiment, effect of 11KT on E2-induced VTG production was examined in vitro. As a result, in both male and female hepatocytes, 11KT enhanced E2-induced VTG production, although 11KT alone failed to induce VTG production.

引用

页码：383 / 384

页数：2