The Seroepidemiology of Haemophilus influenzae Type B Prior to Introduction of an Immunization Programme in Kathmandu, Nepal

被引：4

作者：

Marshall, Andrew S. J. ^{[1
,2
]}

Barker, Charlotte I. S. ^{[1
,2
]}

Pulickal, Anoop S. ^{[1
,2
]}

Kibwana, Elizabeth ^{[1
,2
]}

Gautam, Samir C. ^{[3
]}

Clutterbuck, Elizabeth A. ^{[1
,2
]}

Thorson, Stephen M. ^{[3
]}

Shrestha, Shrijana ^{[3
]}

Adhikari, Neelam ^{[3
]}

Pollard, Andrew J. ^{[1
,2
]}

Kelly, Dominic F. ^{[1
,2
]}

机构：

[1] Univ Oxford, Oxford Vaccine Grp, Oxford, England

[2] NIHR Oxford Biomed Res Ctr, Oxford, England

[3] Patan Hosp, Kathmandu, Nepal

来源：

PLOS ONE | 2014年 / 9卷 / 01期

关键词：

CONJUGATE VACCINE; CAPSULAR POLYSACCHARIDE; ROUTINE IMMUNIZATION; ANTIBODY; CHILDREN; DISEASE; COLONIZATION; PROTECTION; INFANTS;

D O I：

10.1371/journal.pone.0085055

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Haemophilus influenzae type b (Hib) is now recognized as an important pathogen in Asia. To evaluate disease susceptibility, and as a marker of Hib transmission before routine immunization was introduced in Kathmandu, 71 participants aged 7 months-77 years were recruited and 15 cord blood samples were collected for analysis of anti-polyribosylribitol phosphate antibody levels by enzyme-linked immunosorbent assay. Only 20% of children under 5 years old had levels considered protective (>0.15 mu g/ml), rising to 83% of 15-54 year-olds. Prior to introduction of Hib vaccine in Kathmandu, the majority of young children were susceptible to disease.

引用

页数：4

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