Low dose effects and non-monotonic dose responses for endocrine active chemicals: Science to practice workshop: Workshop summary

被引：92

作者：

Beausoleil, Claire ^{[1
]}

Ormsby, Jean-Nicolas ^{[1
]}

Gies, Andreas ^{[2
]}

Hass, Ulla ^{[3
]}

Heindel, Jerrold J. ^{[4
]}

Holmer, Marie Louise ^{[5
]}

Nielsen, Pia Juul ^{[5
]}

Munn, Sharon ^{[6
]}

Schoenfelder, Gilbert ^{[7
]}

机构：

[1] French Agcy Food Environm & Occupat Hlth & Safety, F-94701 Maisons Alfort, France

[2] Fed Environm Agcy UBA, D-14193 Berlin, Germany

[3] Tech Univ Denmark, Natl Food Inst, DK-2860 Soborg, Denmark

[4] NIEHS, NIH, Res Triangle Pk, NC 27709 USA

[5] Environm Protect Agcy, Danish Minist Environm, DK-1401 Copenhagen K, Denmark

[6] Commiss European Communities, Joint Res Ctr, I-21027 Ispra, VA, Italy

[7] Charite, D-10117 Berlin, Germany

来源：

CHEMOSPHERE | 2013年 / 93卷 / 06期

关键词：

Low dose effects; Non-monotonic dose responses; Endocrine disruptors; Risk assessment; DISRUPTING CHEMICALS; STATEMENT; HEALTH;

D O I：

10.1016/j.chemosphere.2013.06.043

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

A workshop was held in Berlin September 12-14th 2012 to assess the state of the science of the data supporting low dose effects and non-monotonic dose responses ("low dose hypothesis") for chemicals with endocrine activity (endocrine disrupting chemicals or EDCs). This workshop consisted of lectures to present the current state of the science of EDC action and also the risk assessment process. These lectures were followed by breakout sessions to integrate scientists from various backgrounds to discuss in an open and unbiased manner the data supporting the "low dose hypothesis". While no consensus was reached the robust discussions were helpful to inform both basic scientists and risk assessors on all the issues. There were a number of important ideas developed to help continue the discussion and improve communication over the next few years. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.

引用

页码：847 / 856

页数：10

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