Pleurectomy/decortication and hyperthermic intrapleural chemotherapy for malignant pleural mesothelioma: initial experience

被引：17

作者：

Migliore, Marcello ^{[1
]}

Calvo, Damiano ^{[1
]}

Criscione, Alessandra ^{[1
]}

Palmucci, Stefano ^{[2
]}

Sanza, Giovanni Fuccio ^{[2
]}

Caltabiano, Rosario ^{[3
]}

Spatola, Corrado ^{[2
]}

Privitera, Giuseppe ^{[2
]}

Aiello, Marco Maria ^{[4
]}

Parra, Hector Soto ^{[4
]}

Ciancio, Nicola ^{[5
]}

Di Maria, Giuseppe ^{[5
]}

机构：

[1] Univ Catania, Policlin Hosp, Dept Gen Surg & Med Special, Thorac Surg Sect, Catania, Italy

[2] Policlin Hosp, Radiodiagnost & Radiotherapy Unit, Catania, Italy

[3] Policlin Hosp, Pathol Unit, Catania, Italy

[4] Policlin Hosp, Oncol Unit, Catania, Italy

[5] Policlin Hosp, Pneumol Unit, Catania, Italy

来源：

FUTURE ONCOLOGY | 2015年 / 11卷 / 24期

关键词：

chemotherapy; cisplatin; cytoreductive surgery; HITHOC; hyperthermic perfusion; mesothelioma; multimodality treatment; VATS; SURGERY; CISPLATIN; PNEUMONECTOMY; SURVIVAL; EFFICACY;

D O I：

10.2217/fon.15.286

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytoreductive surgery and hyperthermic intraoperative intrapleural chemotherapy (HITHOC) are a known option for malignant pleural mesothelioma (MPM). This prospective study was started to prove that pleurectomy/decortication and HITHOC could be successfully performed in a low volume center. Criteria of inclusion were a proven diagnosis of MPM, early-stage disease and good performance status. Six consecutive patients were enrolled. After pleurectomy/decortication, intrapleural cisplatin was administered for 60 min at 42.5 degrees C. Wedge resections and diaphragmatic reconstruction were added in two and one patient, respectively. Morbidity was 16.6%. Mortality was nil. Hospital stay was 7.8 days. Mean survival was 21.5 months (range: 6-30). This small experience confirms that pleurectomy/decortication and HITHOC are a good therapeutic option in the multimodality treatment of MPM. A randomized controlled trial is necessary.

引用

页码：19 / 22

页数：4

共 15 条

[1] Malignant pleural mesothelioma and the Society of Thoracic Surgeons Database: An analysis of surgical morbidity and mortality [J].

Burt, Bryan M. ;

Cameron, Robert B. ;

Mollberg, Nathan M. ;

Kosinski, Andrzej S. ;

Schipper, Paul H. ;

Shrager, Joseph B. ;

Vigneswaran, Wickii T. .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2014, 148 (01) :30-35

[2] Intraoperative hyperthermic chemotherapy perfusion for malignant pleural mesothelioma: An in vitro evaluation [J].

Cameron, Robert B. ;

Hou, Dongmei .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2013, 145 (02) :496-504

[3] A systematic review and meta-analysis of surgical treatments for malignant pleural mesothelioma [J].

Cao, Christopher ;

Tian, David ;

Park, John ;

Allan, James ;

Pataky, Kristopher A. ;

Yan, Tristan D. .

LUNG CANCER, 2014, 83 (02) :240-245

[4] Surgery in the treatment of malignant pleural mesothelioma: recruitment into trials should be the default position [J].

Datta, Avijit ;

Smith, Rhiannon ;

Fiorentino, Francesca ;

Treasure, Tom .

THORAX, 2014, 69 (02) :194-197

[5] Surgeon Specialty and Long-Term Survival After Pulmonary Resection for Lung Cancer [J].

Farjah, Farhood ;

Flum, David R. ;

Varghese, Thomas K. ;

Symons, Rebecca Gaston ;

Wood, Douglas E. .

ANNALS OF THORACIC SURGERY, 2009, 87 (04) :995-1006

[6] Extrapleural pneumonectomy versus pleurectomy/decortication in the surgical management of malignant pleural mesothelioma: Results in 663 patients [J].

Flores, Raja M. ;

Pass, Harvey I. ;

Seshan, Venkatraman E. ;

Dycoco, Joseph ;

Zakowski, Maureen ;

Carbone, Michele ;

Bains, Manjit S. ;

Rusch, Valerie W. .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2008, 135 (03) :620-+

[7] Efficacy and safety of single-trocar technique for minimally invasive surgery of the chest in the treatment of noncomplex pleural disease [J].

Migliore, M .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2003, 126 (05) :1618-1623

[8] A surgeon's case volume of oesophagectomy for cancer strongly influences the operative mortality rate [J].

Migliore, Marcello ;

Choong, Cliff K. ;

Lim, Eric ;

Goldsmith, Kimberley A. ;

Ritchie, Andy ;

Wells, Francis C. .

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2007, 32 (02) :375-379

[9] Cytoreductive surgery and hyperthermic intrapleural chemotherapy for malignant pleural diseases: preliminary experience [J].

Migliore, Marcello ;

Calvo, Damiano ;

Criscione, Alessandra ;

Viola, Cristina ;

Privitera, Giuseppe ;

Spatola, Corrado ;

Parra, Hector Soto ;

Palmucci, Stefano ;

Ciancio, Nicola ;

Caltabiano, Rosario ;

Di Maria, Giuseppe .

FUTURE ONCOLOGY, 2015, 11 (02) :47-52

[10] Assessment of cisplatin concentration and depth of penetration in human lung tissue after hyperthermic exposure [J].

Ried, Michael ;

Lehle, Karla ;

Neu, Reiner ;

Diez, Claudius ;

Bednarski, Patrick ;

Sziklavari, Zsolt ;

Hofmann, Hans-Stefan .

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2015, 47 (03) :563-566

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