Anti-inflammatory and antinociceptive properties of dantrolene sodium in rats and mice

被引：16
作者：
Büyükokuroglu, ME [1 ]
机构：
[1] Ataturk Univ, Fac Med, Dept Pharmacol, TR-25240 Erzurum, Turkey
来源：
PHARMACOLOGICAL RESEARCH | 2002年 / 45卷 / 06期
关键词：
dantrolene sodium; anti-inflammatory; analgesic; rat; mouse;
D O I：
10.1006/phrs.2002.0970
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Our study aimed at examining the possible anti-inflammatory and antinociceptive effects of dantrolene sodium in rats and mice. The anti-inflammatory effect of dantrolene sodium (2.5, 5 and 10 mg kg(-1)) was investigated and compared with diclofenac sodium (5 mg kg(-1)) using the formalin-, histamine-, and carrageenan-induced paw oedema and cotton pellet granuloma tests. Analgesic effects of dantrolene sodium were evaluated and compared with metamizol (200 mg kg(-1)) in acetic acid-induced writhing and formalin-induced paw licking tests. It was found that dantrolene sodium significantly diminished the nociceptive response in mice, showing at the same time considerable anti-inflammatory properties in rats. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：455 / 460
页数：6
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