Targeting the interleukin-15/interleukin-15 receptor system in inflammatory autoimmune diseases

被引：66

作者：

Waldmann, TA ^{[1
]}

机构：

[1] NCI, Metab Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

ARTHRITIS RESEARCH & THERAPY | 2004年 / 6卷 / 04期

关键词：

autoimmune disease; interleukin-15; memory T cells; rheumatoid arthritis;

D O I：

10.1186/ar1202

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Interleukin (IL)-15 is a dangerous inflammatory cytokine that induces tumor-necrosis factor-alpha, IL-1beta and inflammatory chemokines. It inhibits self-tolerance mediated by IL-2 mediated activation-induced cell death and facilitates maintenance of CD8(+) memory T-cell survival including that of self-directed memory cells. Disordered IL-15 expression has been reported in patients with an array of inflammatory autoimmune diseases. A series of therapeutic agents that inhibit IL-15 action have been introduced, including the soluble IL-15 receptor (IL-15R) alpha chain, mutant IL-15, and antibodies directed against the IL-15 cytokine and against the IL-2R/IL-15R beta subunit used by IL-2 and IL-15.

引用

页码：174 / 177

页数：4

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