Mechanisms of Endocytosis

被引：2280
作者：
Doherty, Gary J. [1 ]
McMahon, Harvey T. [1 ]
机构：
[1] MRC, Mol Biol Lab, Cambridge CB2 0QH, England
来源：
ANNUAL REVIEW OF BIOCHEMISTRY | 2009年 / 78卷
基金：
英国医学研究理事会;
关键词：
caveolae; clathrin-mediated endocytosis; clathrin-independent endocytosis; dynamin; small G proteins; CLATHRIN-INDEPENDENT ENDOCYTOSIS; GPI-ANCHORED PROTEINS; EPIDERMAL-GROWTH-FACTOR; KISS-AND-RUN; CAVEOLAE/RAFT-DEPENDENT ENDOCYTOSIS; TUBULAR MEMBRANE INVAGINATIONS; RECEPTOR-MEDIATED PHAGOCYTOSIS; GTPASE-ACTIVATING PROTEIN; CIRCULAR DORSAL RUFFLES; HUMAN BREAST-CANCER;
D O I：
10.1146/annurev.biochem.78.081307.110540
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Endocytic mechanisms control the lipid and protein composition of the plasma membrane, thereby regulating how cells interact with their environments. Here, we review what is known about mammalian endocytic mechanisms, with focus on the cellular proteins that control these events. We discuss the well-studied clathrin-mediated endocytic mechanisms and dissect endocytic pathways that proceed independently of clathrin. These clathrin-independent pathways include the CLIC/GEEC endocytic pathway, arf6-dependent endocytosis, flotillin-dependent endocytosis, macropinocytosis, circular doral ruffles, phagocytosis, and trans-endocytosis. We also critically review the role of caveolae and caveolin1 in endocytosis. We highlight the roles of lipids, membrane curvature-modulating proteins, small G proteins, actin, and dynamin in endocytic pathways. We discuss the functional relevance of distinct endocytic pathways and emphasize the importance of studying these pathways to understand human disease processes.
引用
收藏
页码：857 / 902
页数：46
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