A single-step synthesis of symmetrical 1,3-diarylisobenzofurans

被引：14

作者：

Benderradj, Farah ^{[1
]}

Nechab, Malek ^{[1
]}

Einhorn, Cathy ^{[1
]}

Einhorn, Jacques ^{[1
]}

机构：

[1] Univ Grenoble 1, UMR 5616, Etud Dynam & Struct Select Lab, F-38041 Grenoble 9, France

来源：

SYNLETT | 2006年 / 13期

关键词：

Grignard reactions; Diels-Alder reactions; fused-ring systems; heterocycles; nucleophilic addition;

D O I：

10.1055/s-2006-948179

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient single-step synthesis of various symmetrically substituted 1,3-diarylisobenzofurans from readily available 3-methoxy-3H-isobenzofuran-1-one (1 a) and two equivalents of aryl Grignard reagents is described. The title compounds are obtained in medium to high isolated yields. Crude isobenzofuran has also been trapped by maleimide, furnishing pure Diels-Alder adduct almost quantitatively.

引用

页码：2035 / 2038

页数：4

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