Replicative Stress and Cell Cycle Restriction in G0/G1 Following Genomic DNA Damage and Disruption of ATM Signaling Accounts for Failure of Liver Regeneration and Offers Therapeutic Directions in Acetaminophen (APAP)-induced Acute Liver Failure

被引：0

作者：

Viswanathan, Preeti ^{[1
]}

Sharma, Yogeshwar ^{[2
]}

Bandi, Sriram ^{[2
]}

Gupta, Sanjeev ^{[2
]}

机构：

[1] Childrens Hosp Montefiore, Pediat Gastroenterol & Hepatol, Bronx, NY USA

[2] Albert Einstein Coll Med, Marion Bessin Liver Ctr, Med & Pathol, Bronx, NY 10467 USA

来源：

HEPATOLOGY | 2015年 / 62卷

关键词：

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

1764

引用

页码：1068A / 1069A

页数：2

共 7 条

[1] Acetaminophen (APAP)-induced Hepatotoxicity is Characterized by Greater Susceptibility of Cells in S or G2/M and Prolonged Arrest in G0/G1 with Inability to Reenter Cell Cycle Accounts for Failure of Hepatic Regeneration in Acute Liver Failure (ALF)
Viswanathan, Preeti
Bandi, Sriram
Gupta, Sanjeev
HEPATOLOGY, 2013, 58 : 378A - 378A
[2] Acetaminophen (APAP) Hepatotoxicity Leads To DNA Damage-Induced Arrest of Injured Cells In G0/G1 Through Involvement Of Cell Cycle Regulators
Viswanathan, Preeti
Bandi, Sriram
Gupta, Sanjeev
HEPATOLOGY, 2014, 60 : 717A - 718A
[3] Acetaminophen (APAP)-Induced Hepatotoxicity and Failure of Liver Regeneration Results from Cellular DNA Damage and Replicative Stress that is Reversed via Paracrine Signaling From Healthy Transplanted Cells and Offers New Therapeutic Mechanisms
Viswanathan, Preeti
Bandi, Sriram
Gupta, Sanjeev
HEPATOLOGY, 2013, 58 : 256A - 257A
[4] INVOLVEMENT OF ATAXIA TELANGIECTASIA MUTATED (ATM) SIGNALING PATHWAYS IN ACETAMINOPHEN (APAP)-INDUCED HEPATOTOXICITY OFFERS THERAPEUTIC OPPORTUNITIES FOR ACUTE LIVER FAILURE (ALF)
Viswanathan, Preeti
Bandi, Sriram
Simon, Jeannette Gonzalez
Gupta, Sanjeev
HEPATOLOGY, 2011, 54 : 366A - 366A
[5] Gene Therapy with Candidate microRNAs (miRNA) Capable of Regulating DNA Damage Response Rescues Mice with Acetaminophen (APAP)- induced Acute Liver Failure (ALF) and Offers New Therapeutic Directions
Viswanathan, Preeti
Sharma, Yogeshwar
Bandi, Sriram
Gupta, Sanjeev
HEPATOLOGY, 2016, 64 : 317A - 317A
[6] RESTORATION OF DEFICIENT CYTOKINES INDUCING STAT3 AND ATM SIGNALING REACTIVATE CELL INTERACTIONS FOR LIVER REGENERATION (LR) IN ACETAMINOPHEN (APAP)-INDUCED ACUTE LIVER FAILURE (ALF)
Viswanathan, Preeti
Sharma, Yogeshwar
Jaber, Fadi-Luc
Gupta, Sanjeev
HEPATOLOGY, 2021, 74 : 733A - 733A
[7] Reversal of Ataxia Telangiectasia Mutated (ATM) Signaling Pathway-associated DNA Damage and Acute Liver Failure (ALF) Following Acetaminophen (APAP) Toxicity by Hepatic Support from Extrahepatically Transplanted Hepatocytes
Viswanathan, Preeti
Bandi, Sriram
Gupta, Sanjeev
HEPATOLOGY, 2012, 56 : 967A - 968A

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