Emergency Neurological Life Support: Pharmacotherapy

被引：16

作者：

Brophy, Gretchen M. ^{[1
,2
]}

Human, Theresa ^{[3
]}

Shutter, Lori ^{[4
]}

机构：

[1] Virginia Commonwealth Univ, Dept Pharmacotherapy & Outcomes Sci, Richmond, VA 23284 USA

[2] Virginia Commonwealth Univ, Dept Neurosurg, Richmond, VA USA

[3] Washington Univ, Barnes Jewish Hosp, Dept Clin Pharm, St Louis, MO USA

[4] Univ Pittsburgh, Sch Med, Dept Crit Care Med, Dept Neurol & Neurosurg, Pittsburgh, PA USA

来源：

NEUROCRITICAL CARE | 2015年 / 23卷

关键词：

ENLS; Pharmacotherapy; Medication; Adverse drug event; Drug interaction; PROTHROMBIN COMPLEX CONCENTRATE; HEALTH-CARE PROFESSIONALS; ACTIVATED FACTOR-VII; HYPERTONIC SALINE; EXCESSIVE ANTICOAGULATION; ANTIFIBRINOLYTIC THERAPY; REVERSAL; GUIDELINES; MANAGEMENT; MANNITOL;

D O I：

10.1007/s12028-015-0158-1

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The appropriate use of medications during Emergency Neurological Life Support (ENLS) is essential to optimize patient care. Important considerations when choosing the appropriate agent include the patient's organ function and medication allergies, potential adverse drug effects, drug interactions, and critical illness and aging pathophysiologic changes. Critical medications used during ENLS include hyperosmolar therapy, anticonvulsants, antithrombotics, anticoagulant reversal and hemostatic agents, anti- shivering agents, neuromuscular blockers, antihypertensive agents, sedatives, vasopressors and inotropes, and antimicrobials. This article focuses on the important pharmacokinetic and pharmacodynamics characteristics, advantages and disadvantages, and clinical pearls of these therapies, providing practitioners with essential drug information to optimize pharmacotherapy in acutely ill neurocritical care patients.

引用

页码：S48 / S68

页数：21

共 55 条

[1]

[Anonymous], 2015, LEX COMP IL D

[2]

[Anonymous], 2013, LEX COMP IL D

[3] Predictors and clinical implications of shivering during therapeutic normothermia [J].

Badjatia, Neeraj ;

Kowalski, Robert G. ;

Schmidt, J. Michael ;

Voorhees, Marc E. ;

Claassen, Jan ;

Ostapkovich, Noeleen D. ;

Presciutti, Mary ;

Connolly, E. Sander ;

Palestrant, David ;

Parra, Augusto ;

Mayer, Stephan A. .

NEUROCRITICAL CARE, 2007, 6 (03) :186-191

[4] Metabolic Impact of Shivering During Therapeutic Temperature Modulation The Bedside Shivering Assessment Scale [J].

Badjatia, Neeraj ;

Strongilis, Evangelia ;

Gordon, Errol ;

Prescutti, Mary ;

Fernandez, Luis ;

Fernandez, Andres ;

Buitrago, Manuel ;

Schmidt, J. Michael ;

Ostapkovich, Noeleen D. ;

Mayer, Stephan A. .

STROKE, 2008, 39 (12) :3242-3247

[5] Guidelines on oral anticoagulation (warfarin): third edition - 2005 update [J].

Baglin, TP ;

Keeling, DM ;

Watson, HG .

BRITISH JOURNAL OF HAEMATOLOGY, 2006, 132 (03) :277-285

[6] Prothrombin Complex Concentrates for Oral Anticoagulant Therapy-Related Intracranial Hemorrhage: A Review of the Literature [J].

Bershad, Eric M. ;

Suarez, Jose I. .

NEUROCRITICAL CARE, 2010, 12 (03) :403-413

[7] Recombinant activated factor VII for acute subdural haematoma in an elderly patient taking fondaparinux [J].

Bordes, J. ;

Asencio, Y. ;

Kenane, N. ;

Fesselet, J. ;

Meaudre, E. ;

Goutorbe, P. .

BRITISH JOURNAL OF ANAESTHESIA, 2008, 101 (04) :575-576

[8] Low-dose vitamin K therapy in excessively anticoagulated patients: A dose-finding study [J].

Brophy M.T. ;

Fiore L.D. ;

Deykin D. .

Journal of Thrombosis and Thrombolysis, 1997, 4 (2) :289-292

[9] Guidelines for the Evaluation and Management of Status Epilepticus [J].

Brophy, Gretchen M. ;

Bell, Rodney ;

Claassen, Jan ;

Alldredge, Brian ;

Bleck, Thomas P. ;

Glauser, Tracy ;

LaRoche, Suzette M. ;

Riviello, James J., Jr. ;

Shutter, Lori ;

Sperling, Michael R. ;

Treiman, David M. ;

Vespa, Paul M. .

NEUROCRITICAL CARE, 2012, 17 (01) :3-23

[10] Prothrombinex use for the reversal of warfarin: is fresh frozen plasma needed? [J].

Crawford, JH ;

Augustson, BM .

MEDICAL JOURNAL OF AUSTRALIA, 2006, 184 (07) :365-366

← 1 2 3 4 5 6 →