Enhancing immune responses by targeting antigen to DC

被引：82
作者：
Caminschi, Irina [1 ]
Lahoud, Mireille H. [1 ]
Shortman, Ken [1 ]
机构：
[1] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 2009年 / 39卷 / 04期
基金：
英国医学研究理事会;
关键词：
Clec9A; C-type lectins; DC; Targeting; Vaccination; T-CELL RESPONSES; HUMAN DENDRITIC CELLS; C-TYPE LECTIN; MONOCLONAL-ANTIBODY NLDC-145; FOLLICULAR-HELPER-CELLS; SUBSETS IN-VIVO; STEADY-STATE; CROSS-PRESENTATION; TISSUE DISTRIBUTION; DEC-205; RECEPTOR;
D O I：
10.1002/eji.200839035
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
mAb that recognise various cell surface receptors have been used to deliver antigen to DC and thereby elicit immune responses. The encouraging data obtained in mouse models suggests that this immunisation strategy is efficient and could lead to clinical trials. We discuss a number of issues pertinent to this vaccination approach. These include which molecules are the best targets for delivering antigen to DC, which DC subtypes should be targeted, the types of immune responses to be generated and whether additional adjuvants are required. Finally, we discuss some progress towards targeting antigen to human DC.
引用
收藏
页码：931 / 938
页数：8
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