Molecular Comprehension of Mcl-1: From Gene Structure to Cancer Therapy

被引：78
作者：
Senichkin, Viacheslav V. [1 ]
Streletskaia, Alena Y. [1 ]
Zhivotovsky, Boris [1 ,2 ]
Kopeina, Gelina S. [1 ]
机构：
[1] Moscow MV Lomonosov State Univ, Fac Med, Moscow, Russia
[2] Karolinska Inst, Inst Environm Med, Stockholm, Sweden
来源：
TRENDS IN CELL BIOLOGY | 2019年 / 29卷 / 07期
基金：
俄罗斯科学基金会; 俄罗斯基础研究基金会;
关键词：
PRE-MESSENGER-RNA; CELL-DEATH; MITOCHONDRIAL DYNAMICS; MYELOMA CELLS; BH3; DOMAIN; BCL-2; APOPTOSIS; BAK; INHIBITOR; PROTEINS;
D O I：
10.1016/j.tcb.2019.03.004
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Among cell death regulators, members of the Bcl-2 family are of interest because they are highly conserved across species and represent promising targets for anticancer therapy. This family and its associated proteins include more than 25 members, with either anti- or proapoptotic functions. Although the overall regulation of apoptosis by Bcl-2 family proteins is now well understood, targeted therapy requires careful consideration of individual members of the family and their crosstalk. One of the most studied representatives of the Bcl-2 family is antiapoptotic Mcl-1. After 25 years of investigations, a large amount of data regarding Mcl-1's regulation and functions has been compiled. In this review, we summarize current knowledge about Mcl-1, focusing on molecular aspects relevant to Mcl-1 -targeted therapies.
引用
收藏
页码：549 / 562
页数：14
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