Enzyme targeting strategies for prevention and treatment of cancer: Implications for cancer therapy

被引：84

作者：

Baig, Mohammad Hassan ^{[1
]}

Adil, Mohd ^{[2
]}

Khan, Rosina ^{[3
]}

Dhadi, Surendar ^{[4
]}

Ahmad, Khurshid ^{[1
]}

Rabbani, Gulam ^{[1
]}

Bashir, Tufail ^{[1
]}

Imran, Mohammad Azhar ^{[5
]}

Husain, Fohad Mabood ^{[6
]}

Lee, Eun Ju ^{[1
]}

Kamal, Mohammad Amjad ^{[7
,8
,9
]}

Choi, Inho ^{[1
]}

机构：

[1] Yeungnam Univ, Dept Med Biotechnol, 280 Daehak Ro, Gyongsan, Gyeongbuk, South Korea

[2] Dalhousie Univ, Cox Inst, Halifax, NS, Canada

[3] King Khalid Univ, Coll Appl Med Sci, Dept Publ Hlth, Abha, Saudi Arabia

[4] Atlantic Canc Res Inst Moncton, Moncton, NB, Canada

[5] Aligarh Muslim Univ, JN Med Coll, Dept Biochem, Aligarh, Uttar Pradesh, India

[6] King Saud Univ, Fac Food & Agr Sci, Dept Food Sci & Nutr, Riyadh 2460, Saudi Arabia

[7] King Abdulaziz Univ, King Fahd Med Res Ctr, POB 80216, Jeddah 21589, Saudi Arabia

[8] Enzymoics, 7 Peterlee Pl, Hebersham, NSW 2770, Australia

[9] Novel Global Community Educ Fdn, Hebersham, NSW, Australia

来源：

SEMINARS IN CANCER BIOLOGY | 2019年 / 56卷

关键词：

Enzymes; Cancer; Glycolysis; Biomarkers; Therapy; PENTOSE-PHOSPHATE PATHWAY; PYRUVATE-KINASE M2; PLASMINOGEN-ACTIVATOR SYSTEM; BREAST-CANCER; ALDEHYDE DEHYDROGENASE; ALKALINE-PHOSPHATASE; MATRIX METALLOPROTEINASES; PROSTATE-CANCER; GLUCOSE-6-PHOSPHATE-DEHYDROGENASE EXPRESSION; SYNTHASE ACTIVITY;

D O I：

10.1016/j.semcancer.2017.12.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Extensive growth of cancer in humans is a major cause of death. Numerous studies are being conducted to improve the early diagnosis, prevention, and treatment of cancer. Recent technological advancements in medical science and research indicate molecular target therapy holds much promise in cancer treatment. In the past, therapeutic and diagnostic targeting of non-glycolytic and glycolytic enzymes in cancer have been successful, and discoveries of biomarker enzymes in cancer hold promise for therapeutic treatments. In this review, we discuss the roles of several cancer-associated enzymes that could potentially act as therapeutic targets, and place special focus on non-glycolytic and glycolytic enzymes. This review indicates that the targeting of metabolic signaling offers a promising means of developing novel anti-cancer therapies.

引用

页码：1 / 11

页数：11

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