Therapy-related myelodysplasia and leukemia occur infrequently following VP-16 priming and autotransplantation without total body irradiation

被引：9

作者：

Copelan, E

Hoshaw-Woodard, S

Elder, P

Penza, S

Farag, S

Marcucci, G

Lin, T

Ezzone, S

Scholl, MD

Bechtel, T

Lemeshow, S

Avalos, B

机构：

[1] Ohio State Univ, Med Ctr, Arthur G James Canc Hosp, Bone Marrow Transplantat Program, Columbus, OH 43210 USA

[2] Ohio State Univ, Med Ctr, Richard J Solove Res Inst, Columbus, OH 43210 USA

[3] Ohio State Univ, Med Ctr, Arthur G James Canc Hosp, Biostat Program, Columbus, OH 43210 USA

[4] Ohio State Univ, Med Ctr, Arthur G James Canc Hosp, Dept Pharm, Columbus, OH 43210 USA

来源：

BONE MARROW TRANSPLANTATION | 2004年 / 34卷 / 01期

关键词：

secondary AML; autotransplantation; VP-16;

D O I：

10.1038/sj.bmt.1704532

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The use of VP-16 for stem cell mobilization has been cited as a significant risk factor for the development of therapy-related myelodysplasia/leukemia (tMDS/tAML) following autologous transplantation. The present study analyzed a large cohort of patients who underwent autotransplantation following stem cell mobilization with VP-16 and radiation-free preparation in order to determine the risk of tMDS/tAML. The estimated incidence of 9.9% at 7 years suggests that in the absence of TBI, VP-16 priming is not associated with an increased incidence of tMDS/tAML.

引用

页码：85 / 87

页数：3

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