L-carnitine alleviates sciatic nerve crush injury in rats: functional and electron microscopy assessments

被引：10
作者：
Avsar, Ummu Zeynep [1 ]
Avsar, Umit [2 ]
Aydin, Ali [3 ]
Yayla, Muhammed [4 ]
Ozturkkaragoz, Berna [5 ]
Un, Harun [6 ]
Saritemur, Murat [7 ]
Mercantepe, Tolga [8 ]
机构：
[1] Ataturk Univ, Fac Med, Dept Med Educ, TR-25240 Erzurum, Turkey
[2] Ataturk Univ, Fac Med, Dept Family Med, TR-25240 Erzurum, Turkey
[3] Ataturk Univ, Fac Med, Dept Orthoped & Traumatol, TR-25240 Erzurum, Turkey
[4] Ataturk Univ, Fac Med, Dept Pharmacol, TR-25240 Erzurum, Turkey
[5] Agri Univ, Fac Pharm, Dept Pharmacol, Agri, Turkey
[6] Agri Univ, Fac Pharm, Dept Biochem, Agri, Turkey
[7] Ataturk Univ, Fac Med, Dept Emergency Med, TR-25240 Erzurum, Turkey
[8] Ataturk Univ, Fac Med, Dept Histol & Embryol, TR-25240 Erzurum, Turkey
来源：
NEURAL REGENERATION RESEARCH | 2014年 / 9卷 / 10期
关键词：
nerve regeneration; peripheral nerve injury; sciatic nerve; L-carnitine; neuroprotection; crush injury; electron microscopy; axon; myelin sheath; neural regeneration; ACETYL-L-CARNITINE; ALZHEIMERS-DISEASE; L-ACETYLCARNITINE; OXIDATIVE STRESS; REGENERATION; ANTIOXIDANT; DYSFUNCTION; CONDUCTION; PROTECTS; PROMOTES;
D O I：
10.4103/1673-5374.133163
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Several studies have demonstrated that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats with diabetes mellitus. It is hypothesized that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats. Rat sciatic nerve was crush injured by a forceps and exhibited degenerative changes. After intragastric administration of 50 and 100 mg/kg L-carnitine for 30 days, axon area, myelin sheath area, axon diameter, myelin sheath diameter, and numerical density of the myelinated axons of injured sciatic nerve were similar to normal, and the function of injured sciatic nerve also improved significantly. These findings suggest that L-camitine exhibits neuroprotective effects on sciatic nerve crush injury in rats.
引用
收藏
页码：1020 / 1024
页数：5
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