A Clonogenic Progenitor with Prominent Plasmacytoid Dendritic Cell Developmental Potential

被引：154

作者：

Onai, Nobuyuki ^{[1
,2
]}

Kurabayashi, Kazutaka ^{[1
]}

Hosoi-Amaike, Mayuka ^{[1
]}

Toyama-Sorimachi, Noriko ^{[3
]}

Matsushima, Kouji ^{[2
,4
]}

Inaba, Kayo ^{[2
,5
]}

Ohteki, Toshiaki ^{[1
,2
]}

机构：

[1] Tokyo Med & Dent Univ, Med Res Inst, Dept Biodef Res, Tokyo 1138510, Japan

[2] Core Res Evolut Sci & Technol, Japan Sci & Technol Agcy, Tokyo 1020081, Japan

[3] Natl Ctr Global Hlth & Med, Res Inst, Dept Mol Immunol & Inflammat, Tokyo 1628655, Japan

[4] Univ Tokyo, Grad Sch Med, Dept Mol Prevent Med, Tokyo 1130033, Japan

[5] Kyoto Univ, Grad Sch Biostudies, Div Syst Life Sci, Lab Immunobiol,Dept Anim Dev & Physiol, Kyoto 6068501, Japan

来源：

IMMUNITY | 2013年 / 38卷 / 05期

基金：

日本科学技术振兴机构;

关键词：

INTERFERON-PRODUCING CELLS; TRANSCRIPTION FACTOR E2-2; I INTERFERON; FLT3; LIGAND; REPORTER GENE; CUTTING EDGE; STEADY-STATE; LYMPH-NODES; PRECURSORS; MACROPHAGES;

D O I：

10.1016/j.immuni.2013.04.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Macrophage and dendritic cell (DC) progenitors (MDPs) and common DC progenitors (CDPs) are bone marrow (BM) progenitors with DC differentiation potential. However, both MDPs and CDPs give rise to large numbers of conventional DCs (cDCs) and few plasmacytoid DCs (pDCs), implying that more dedicated pDC progenitors remain to be identified. Here we have described DC progenitors with a prominent pDC differentiation potential. Although both MDPs and CDPs express the macrophage colony stimulating factor (M-CSF) receptor (M-CSFR), the progenitors were confined to a M-CSFR- fraction, identified as Lin(-)c-Kit(int/lo)Flt3(+)M-CSFR-, and expressed high amounts of E2-2 (also known as Tcf4) an essential transcription factor for pDC development. Importantly, they appeared to be directly derived from either CDPs or lymphoid-primed multi-potent progenitors (LMPPs). Collectively, our findings provide insight into DC differentiation pathways and may lead to progenitor-based therapeutic applications for infection and autoimmune disease.

引用

页码：943 / 957

页数：15

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