Chemistry of insect antifeedants from Azadirachta indica .21. Synthesis of model compounds of azadirachtin using a decalin framework as a functional group scaffolding

被引：11
作者：
delaPuente, ML
Ley, SV
Simmonds, MSJ
Blaney, WM
机构：
[1] UNIV CAMBRIDGE,DEPT CHEM,CAMBRIDGE CB2 1EW,ENGLAND
[2] ROYAL BOT GARDENS,JODRELL LAB,BIOL INTERACT SECT,BEHAV ENTOMOL GRP,RICHMOND TW9 3AB,SURREY,ENGLAND
[3] UNIV LONDON BIRKBECK COLL,BEHAV ENTOMOL GRP,LONDON,ENGLAND
来源：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1996年 / 13期
关键词：
D O I：
10.1039/p19960001523
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An investigation has been carried out of the synthesis of structural models for the left hand portion of the natural product azadirachtin 1. This work has culminated in a concise and high-yielding route to decalin derivative 2. The significant antifeedant activity shown by this mimic 2 (AI(50) at 9.4 ppm) is greater than that of the other analogues synthesised during this study and has led to the synthesis of further mimics 3 and 4.
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页码：1523 / 1529
页数：7
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