Vaccine immunity against fungal infections

被引：31
作者：
Nanjappa, Som G. [1 ]
Klein, Bruce S. [1 ,2 ,3 ]
机构：
[1] Univ Wisconsin, Sch Med & Publ Hlth, Dept Pediat, Madison, WI 53792 USA
[2] Univ Wisconsin, Sch Med & Publ Hlth, Dept Internal Med, Madison, WI 53792 USA
[3] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med Microbiol & Immunol, Madison, WI 53792 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2014年 / 28卷
关键词：
CD8(+) T-CELLS; ASPERGILLUS-FUMIGATUS PROTEINS; HISTOPLASMA-CAPSULATUM; CRYPTOCOCCUS-NEOFORMANS; PNEUMOCYSTIS-CARINII; INVASIVE ASPERGILLOSIS; INDUCED PROTECTION; CANDIDA-ALBICANS; DEFICIENT HOSTS; NORTH-AMERICA;
D O I：
10.1016/j.coi.2014.01.014
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Only a handful of the many fungal species on our planet cause infections in humans. Despite many medical advances, invasive fungal infections have skyrocketed in recent years and pose a growing health problem in both immune-competent and immune-deficient hosts. Recent strides in our understanding of fungal immunity have raised the prospect that vaccines against fungi can be developed that are effective, safe and able to elicit lasting immunity even in immune deficient individuals. We discuss progress in vaccine development and understanding mechanisms of protection against fungi including in patients with impaired CD4+ T-cell immunity. © 2014 Elsevier Ltd.
引用
收藏
页码：27 / 33
页数：7
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